4D Oriented Dynamic Scaffold for Promoting Peripheral Nerve Regeneration and Functional Recovery

Neurological function recovery after peripheral nerve injury (PNI) is exceptionally challenging, chiefly because neurons cannot efficiently proliferate, differentiate, and form regenerated axons to pass through the defect region expeditiously and transmit neurological signals. In this study, a four‐...

Full description

Saved in:
Bibliographic Details
Published in:Advanced functional materials 2024-01, Vol.34 (2)
Main Authors: Sun, Mouyuan, You, Dongqi, Zhan, Ning, Liu, Chao, Zhang, Xiaoting, Lin, Lining, Zhang, Jingyu, Lou, Yiting, Chen, Yuewei, Liu, Chundi, Wang, Huiming, He, Yong, Yu, Mengfei
Format: Article
Language:English
Subjects:
Axons
Controllability
Defects
Differentiation
Peripheral nerves
Recovery
Restoration
Scaffolds
Shape memory
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Neurological function recovery after peripheral nerve injury (PNI) is exceptionally challenging, chiefly because neurons cannot efficiently proliferate, differentiate, and form regenerated axons to pass through the defect region expeditiously and transmit neurological signals. In this study, a four‐dimensional (4D) oriented dynamic scaffold is constructed based on shape memory polymer (SMP), which can regulate spatiotemporally controllable neuronal early adequate proliferation, subsequently effective differentiation and axon formation by synergizing the on‐demand microtopography and deformation force‐based mechanical stimuli (DFMS). This dynamic scaffold can accelerate the restoration of large segmental nerve defects, elevate the neural signaling efficiency by 60% compared with static scaffold, and finally form the functionalized robust regenerating nerve fascicles with comparable therapeutic effects on autologous nerve transplantation. Furthermore, the crucial role of Piezo1/Camk2b modulated neuronal differentiation and axon extension is also revealed through deep transcriptomic analysis. In summary, the 4D oriented dynamic scaffold can precisely and remotely regulate neuronal behavior and fate in a non‐invasive way, which has excellent potential for clinical application in peripheral nerve restoration.
ISSN:1616-301X
1616-3028
DOI:10.1002/adfm.202305827