Fabrication and characterization of PLLA/PCL/Mg‐Zn‐Y alloy composite stent

Bioresorbable polymeric stents (BPS) can become a promising alternative over permanent stents, as it reduce in‐stent thrombosis, endothelial dysfunction, and thrombogenicity. Although, a few limitations like uncontrolled degradation, inadequate strength, and lack of radiopacity restrict its applicat...

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Published in:Polymer engineering and science 2024-01, Vol.64 (1), p.243-253
Main Authors: Srivastava, Alok, Singh, Shweta, Agrawal, Mohit, Bhati, Pooja, Kumari, Nisha, Pandya, Madhur, Vashisth, Priya, Chauhan, Pankaj, Bhatnagar, Naresh
Format: Article
Language:English
Subjects:
Alloys
Atomic properties
Biocompatibility
Biomedical materials
Biopolymer
Bioresorbable polymer
Chemical properties
Composite stents
Compressive strength
Crimping
Design and construction
Folding
Magnesium base alloys
Materials
Microparticles
Polylactic acid
Polymers
Radiopacity
Recoil
Stent (Surgery)
Stents
Thrombosis
Tubes
Zinc
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Summary:Bioresorbable polymeric stents (BPS) can become a promising alternative over permanent stents, as it reduce in‐stent thrombosis, endothelial dysfunction, and thrombogenicity. Although, a few limitations like uncontrolled degradation, inadequate strength, and lack of radiopacity restrict its application. Thus, a novel bioresorbable radiopaque Mg‐Zn‐Y Alloy (BRM) of high effective atomic number (Zeff) was developed to reinforce and attenuate X‐rays in the polymers. After that, the optimized BRM microparticles were blended with radiolucent poly (L‐lactide)/poly (ε‐caprolactone) (PLLA/PCL) polymer and extruded into biaxially expanded (BAE) tubes. Further, in this work, BAE tubes of PLLA/PCL/BRM and PLLA/PCL were cut using the optimized Femtosecond laser machine (FSLM) parameters for fabricating cardiovascular stents. These stent materials were assessed to sustain the angioplasty procedure, such as radial strength, crimping, recoil, expansion process, and performance under cycling loading. Highlights A novel biodegradable radiopaque Mg‐Zn‐Y alloy was developed. Adding Mg alloy (5% wt.) in PLLA/PCL imparts X‐ray visibility. Composite stents show better compressive radial strength and flexibility. It also reveals low crimping recoil, expansion recoil, and foreshortening. Composite stents can withstand arterial vasomotion better than PLLA/PCL. Production, Fabrication and Testing of Bioresorbable Radiopaque Composite Stents.
ISSN:0032-3888
1548-2634
DOI:10.1002/pen.26543