P1 Comparative evaluation of clinical efficacy of whey extensively hydrolyzed formula and casein-based extensively hydrolyzed formula in infants with cow’s milk protein allergy

Background and aimsCow’s milk protein allergy (CMPA) is the most common food allergy in children. Eliminating diet plays a key role in CMPA management and extensively hydrolyzed formulas are used. The aim of study was to compare the efficacy of whey extensively hydrolyzed formula (eWHF) and casein-b...

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Bibliographic Details
Published in:Archives of disease in childhood 2017-06, Vol.102 (Suppl 2), p.A35-A35
Main Authors: E, Borovik Tatiana, V, Bushueva Tatiana, A, Skvortsova Vera, G, Zvonkova Natalia, M, Guseva Irina
Format: Article
Language:English
Subjects:
Allergies
Allergy
Atopic dermatitis
Babies
Body weight gain
Bovine serum albumin
Casein
Comparative Analysis
Cow's milk
Dermatitis
Diet
Food allergies
Food intake
Immunoglobulin E
Immunological tolerance
Infants
Milk
Patients
Pediatrics
Proteins
Whey
Young Children
β-Lactoglobulin
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Summary:Background and aimsCow’s milk protein allergy (CMPA) is the most common food allergy in children. Eliminating diet plays a key role in CMPA management and extensively hydrolyzed formulas are used. The aim of study was to compare the efficacy of whey extensively hydrolyzed formula (eWHF) and casein-based extensively hydrolyzed formula (eCHF) in infants with cow’s milk protein allergy.Methods66 infants (4 to 12 months of age) with moderate and severe forms of CMPA were divided into 2 groups and received either eWHF (n=20) or eCHF (n=46) during 5 week period. SCORAD index, specific-IgE levels, weight gain were evaluated before and after study.ResultsAtopic dermatitis was present for 56.4% (37) infant, gastrointestinal (GI) symptoms took place in 8.8% (6), and combined skin and GI symptoms – in 34.8% (23) patients. Elevated specific-IgE level was found to bovine serum albumin (34.5%), casein (15.5%), β-lactoglobulin (19%) and to goat’s milk protein (43.1%). Diagnostic levels of antibodies to eWHF were detected in 12.1% (0,250–0,292 ng/ml), to eCHF in none of patients (0042 ng/ml). SCORAD index decreased in eWHF group from 44.0 to 16.3 in moderate forms and from 73.1 to 50.7 in severe forms. In eCHF group these scores decreased from 42.9 to 5.3 and from 83.1 to 9.7 respectively (p
ISSN:0003-9888
1468-2044
DOI:10.1136/archdischild-2017-313273.89