Inhibitors of the Formation of Advanced Glycation End Products Based on Pyridoxine Azo Derivatives

Several pyridoxine azo derivatives have been synthesized and their in vitro antiglycation activity has been studied. It has been found that the synthesized compounds are more active in terms of IC 50 than aminoguanidine (by factors of 6–21) and pyridoxamine (by factors of 1.8–5.6). The in vivo study...

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Bibliographic Details
Published in:Russian journal of general chemistry 2023-12, Vol.93 (Suppl 2), p.S522-S527
Main Authors: Strelnik, A. D., Agafonova, M. N., Litvinov, R. A., Kazakova, R. R., Belova, M. A., Badeev, Yu. V., Gnezdilov, O. I., Shtyrlin, Yu. G., Spasov, A. A.
Format: Article
Language:English
Subjects:
Biocompatibility
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
In vivo methods and tests
Medical colleges
Pyridoxine
Synthesis
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Summary:Several pyridoxine azo derivatives have been synthesized and their in vitro antiglycation activity has been studied. It has been found that the synthesized compounds are more active in terms of IC 50 than aminoguanidine (by factors of 6–21) and pyridoxamine (by factors of 1.8–5.6). The in vivo study of acute toxicity of the most potent compound has shown their safety (LD 50 > 2000 mg/kg).
ISSN:1070-3632
1608-3350
DOI:10.1134/S107036322315015X