Bovine Serum Albumin (BSA) Mediated Efficient One Pot Synthesis of 3,3′-(Phenylmethanediyl)bis(4-hydroxy-6-methyl-2H-pyran-2-one) Derivatives and Their Biological Studies

• Published in: Russian journal of bioorganic chemistry 2023-12, Vol.49 (Suppl 1), p.S187-S201
• Main Authors: Manjunatha, B., Bodke, Yadav D., Kenchappa, R., Meghana, P., Navaneethgowda, P. V.
• Format: Article
• Language: English
• Subjects: Biochemistry; Biomedical and Life Sciences; Biomedicine; Bioorganic Chemistry; Cattle; Life Sciences; Molecular docking; NMR; Nuclear magnetic resonance; Organic Chemistry; Serum albumin; Substrates; Synthesis
• ISSN: 1068-1620; 1608-330X
• DOI: 10.1134/S1068162023080174

In this work, biocatalysis was achieved by the synthesis of 3,3′-(phenylmethanediyl)bis(4-hydroxy6-methyl-2 H -pyran-2-one) derivatives ( IIIa–IIIh ) using Bovine Serum Albumin (BSA) as a catalyst. Substrate scope and various parameters involved on yield and time of the synthesis were investigated. The structure elucidation of the synthesised targets was assessed through different spectroscopic techniques like FT-IR, 1 H NMR, 13 C NMR, and HR-MS analysis. Bio potency of the synthesised conjugates was examined towards anti-bacterial activity and most of the compounds showed effective results. Further, the anti-inflammatory activity of the synthesised compounds was evaluated against MMP-2 and MMP-9 using gelatine zymography. All the synthesised derivatives inhibited MMP-2 to good extent but displayed a moderate inhibition against MMP-9. Also the molecular docking studies were carried out to determine the interaction of synthesised bis-4-hydroxy-6-methyl-pyran-2-onederivatives with COX-2 receptor.