The effect of biologically active substances on BSA and on the textures of films obtained by drying water-salt solutions of BSA

• Published in: Low temperature physics (Woodbury, N.Y.) N.Y.), 2024-01, Vol.50 (1), p.48-55
• Main Authors: Gorobchenko, O. A., Glibitskiy, D. M., Nikolov, O. T., Cheipesh, T. A., Dzhimieva, T. N., Zaitseva, I. S., Roshal, A. D., Semenov, M. A., Glibitskiy, G. M.
• Format: Article
• Language: English
• Subjects: Aluminum chloride; Aqueous environments; Biological effects; Biopolymers; Ferric chloride; Halides; Iron chlorides; Photon correlation spectroscopy; Polydispersity; Saline solutions; Serum albumin; Sodium halides
• ISSN: 1063-777X; 1090-6517
• DOI: 10.1063/10.0023892

In the previously published results, we studied the effect of flavin mononucleotide (FMN), sodium halides NaF and NaBr, iron chloride FeCl3 and aluminum chloride AlCl3 on zigzag patterns of films obtained from saline solutions of bovine serum albumin (BSA). Changes in the properties of the biopolymer and its aqueous environment in solutions were monitored by UV absorption and fluorescence spectroscopy, microwave dielectrometry and dynamic light scattering. This work summarizes the obtained results on the influence of components of various nature on BSA and its film textures. Changes in the parameters of zigzag patterns are associated with polydispersity due to the presence of colloidal particles, aggregates and FMN associates, as well as a decrease in the surface potential and BSA hydration. The possibility of predicting the character of the influence of the studied biologically active substances on BSA is analyzed.