Balancing at the edge of excitability: implications for cell movement

Cells rely on the ability to sense and respond to small spatial differences in chemoattractant concentrations for survival. There is growing evidence that this is accomplished by setting the signaling system near the threshold for activation in an excitable system and using the spatial heterogeneiti...

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Bibliographic Details
Published in:Mathematics of control, signals, and systems signals, and systems, 2024-03, Vol.36 (1), p.121-137
Main Authors: Biswas, Debojyoti, Banerjee, Parijat, Iglesias, Pablo A.
Format: Article
Language:English
Subjects:
Adaptation
Cells
Communications Engineering
Control
Equilibrium
Explicit knowledge
Mathematics
Mathematics and Statistics
Mechatronics
Networks
Original Article
Papers dedicated to Eduardo D. Sontag on the occasion of his 70th birthday
Robotics
Signalling systems
Simulation
Systems Theory
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Summary:Cells rely on the ability to sense and respond to small spatial differences in chemoattractant concentrations for survival. There is growing evidence that this is accomplished by setting the signaling system near the threshold for activation in an excitable system and using the spatial heterogeneities to alter the threshold, thereby biasing cell activity in the direction of the gradient. Here we consider a scheme by which the set point is adaptively set near the bifurcation point, but without explicit knowledge of this point. Through simulation, we show that the method would improve chemotactic efficiency of cells. The results of this paper are based on pioneering work by Eduardo Sontag and coworkers, to whom this paper is dedicated in honor of his 70th birthday.
ISSN:0932-4194
1435-568X
DOI:10.1007/s00498-023-00361-6