Lymphocyte-related ratios, systemic immune-inflammatory and systemic inflammatory response index in alcohol use disorder

Addictive disorders are associated with systemic and central nervous system inflammation, which may be important for the onset and development of these diseases. Although lymphocyte-related parameters have recently been studied in alcohol use disorder (AUD), systemic immune-inflammation index (SII)...

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Bibliographic Details
Published in:Journal of immunoassay & immunochemistry 2024-01, Vol.45 (1), p.38-49
Main Authors: Kok Kendirlioglu, Burcu, Arat Celik, Hidayet Ece, Buyuksandalyaci Tunc, Ayse Ece, Ozmen, Melike, Corekli Kaymakcı, Esma, Demir, Sevin, Kuçukgoncu, Suat
Format: Article
Language:English
Subjects:
Addictions
Alcohol Drinking
Alcohol use
Alcohol use disorder
Alcoholic beverages
Alcoholism
Central nervous system
Cross-Sectional Studies
Humans
Inflammation
Inflammatory response
Leukocytes (neutrophilic)
Liver
Lymphocytes
monocyte-to-lymphocyte ratio (MLR)
Monocytes
neuroinflammation
neutrophil-to-lymphocyte ratio (NLR)
Ratios
Retrospective Studies
systemic inflammation index
Systemic Inflammatory Response Syndrome
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Summary:Addictive disorders are associated with systemic and central nervous system inflammation, which may be important for the onset and development of these diseases. Although lymphocyte-related parameters have recently been studied in alcohol use disorder (AUD), systemic immune-inflammation index (SII) and systemic inflammatory response index (SIRI) haven't. Lymphocyte-related ratios, SII and SIRI levels were evaluated between AUD and healthy controls (HC) in this study. It was a retrospective and cross-sectional study. This study included 72 patients with AUD and 184 individuals in the HC group. Lymphocyte related ratios such as neutrophil to lymphocyte ratio (NLR), monocyte to lymphocyte ratio (MLR) and platelet to lymphocyte ratio (PLR), SII and SIRI values were compared. Compared to HC group, NLR (p 
ISSN:1532-1819
1532-4230
DOI:10.1080/15321819.2023.2277806