Chitosan oligosaccharides attenuate programmed necrosis induced by oxidative stress in spermatogonia cells

Oxidative stress (OS) has been considered as the main mediator of male infertility by causing abnormal sperm production and function, and, therefore, exploration of natural antioxidant has attracted a great deal of attention in human reproduction. Chitosan and its derivatives exhibit great antioxida...

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Bibliographic Details
Published in:CYTA: journal of food 2023-12, Vol.21 (1), p.285-292
Main Authors: Zhang, Sudan, Dong, Xiaolei, Liu, Jiane, Yang, Chaozhong, Han, Baoqin, Li, Bing, Wang, Zheng
Format: Article
Language:English
Subjects:
Antibodies
Antioxidants
Biotechnology
Cell culture
Cell viability
Chitosan
COS
Degree of polymerization
Endoplasmic reticulum
Infertility
Kinases
male infertility
mitochondria function
Necrosis
Oligosaccharides
Oxidation
Oxidative stress
Polymerization
programmed necrosis
Proteins
Reactive oxygen species
Reproductive health
Software
Sperm
Spermatogenesis
Spermatogonia
Statistical analysis
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Summary:Oxidative stress (OS) has been considered as the main mediator of male infertility by causing abnormal sperm production and function, and, therefore, exploration of natural antioxidant has attracted a great deal of attention in human reproduction. Chitosan and its derivatives exhibit great antioxidant potential in various diseases, whereas the protective functions are not defined in spermatogenesis. Here, we show that chitosan oligosaccharide (COS), a degradation product of chitosan with a degree of polymerization of less than 10, is a strong antioxidant in spermatogonia cells. COS treatment reduces t-BHP-induced reactive oxygen species overproduction and programmed necrosis in GC-1 spg cells, and improves mitochondrial functions and cell viability by inhibiting excessive endoplasmic reticulum stress. Our findings provide novel insight into the protective role of COS in germ cell damage.
ISSN:1947-6337
1947-6345
DOI:10.1080/19476337.2023.2196329