The effects of propolis on doxorubicin-induced hepatorenal damage: a comparison of ethanolic and oily extracts of propolis

The protective effect of ethanolic propolis extract (PE) in the toxic effects of doxorubicin (DOX), a chemotherapy drug, has been reported previously. Since ethanol usage has some restrictions, in the present study, olive oil as an alternative to ethanol has been tested in DOX-induced hepatorenal in...

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Published in:CYTA: journal of food 2023-12, Vol.21 (1), p.666-673
Main Authors: Cirrik, Selma, Kabartan Cokelİ, Emel, Gulec Peker, Emine Gulceri, Hacioglu, Gulay
Format: Article
Language:English
Subjects:
Acids
Cancer
Chemotherapy
Doxorubicin
Ethanol
ethanolic propolis extract
Flavonoids
Functionals
kidney
liver
Medicine
Nitrates
Oily propolis extract
Olive oil
Oxidative stress
Physiology
Propolis
Side effects
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Summary:The protective effect of ethanolic propolis extract (PE) in the toxic effects of doxorubicin (DOX), a chemotherapy drug, has been reported previously. Since ethanol usage has some restrictions, in the present study, olive oil as an alternative to ethanol has been tested in DOX-induced hepatorenal injury and the effectiveness of the two extracts were compared. Male rats were orally given PE or oily propolis extract (PO) for 15 days (50 mg/kg/day) and DOX was injected (15 mg/kg, intraperitoneally) on the 13 th day. The animals were sacrificed and then hepatorenal oxidative stress and functional parameters were evaluated. DOX-induced reduction in hepatorenal functions and oxidative stress were significantly reduced in both propolis treatment groups. Treatment with PO was more effective in reducing DOX-induced oxidative stress, yet both extracts showed similar efficacy in improving hepatorenal functions. We suggest that the PO could be preferred to avoid the side effects of ethanol.
ISSN:1947-6337
1947-6345
DOI:10.1080/19476337.2023.2274370