Stereoselective β‐Arylation of Enol Ethers by a Pd‐Catalyzed Fujiwara‐Moritani Coupling of α‐Oxyacrylates

Herein, Pd(II)‐catalyzed dehydrogenative Heck coupling of 2‐oxyacrylates with arenes for the stereocontrolled production of (Z)‐β‐arylated vinyl ethers is reported. This methodology offers a straightforward and step‐economical route to the synthesis of attractive β‐arylated α‐oxy α,β‐unsaturated car...

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Bibliographic Details
Published in:European journal of organic chemistry 2024-01, Vol.27 (4), p.n/a
Main Authors: Traboulsi, Iman, Hachem, Mahmoud, Schneider, Cédric, Hoarau, Christophe
Format: Article
Language:English
Subjects:
Aromatic compounds
Carboxylates
Coupling
C−H activation
Dehydrogenation
dehydrogenative Heck reaction
enol ethers
Pd catalysis
Stereoselectivity
Vinyl ethers
β-arylation
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Summary:Herein, Pd(II)‐catalyzed dehydrogenative Heck coupling of 2‐oxyacrylates with arenes for the stereocontrolled production of (Z)‐β‐arylated vinyl ethers is reported. This methodology offers a straightforward and step‐economical route to the synthesis of attractive β‐arylated α‐oxy α,β‐unsaturated carboxylates family which emerged as a relevant class of building blocks with different applications. Regio‐ and stereocontrolled synthesis of β‐(Z)‐arylated vinyl ethers by stereoselective dehydrogenative Heck reaction in the presence of various 2‐oxyacrylates under palladium catalysis.
ISSN:1434-193X
1099-0690
DOI:10.1002/ejoc.202301074