Biocompatible and bioadhesive hydrogels based on 2-hydroxyethyl methacrylate, monofunctional poly(alkylene glycol)s and itaconic acid

SummaryNovel poly(Bisomer/HEMA/IA) hydrogels were prepared by radical copolymerization of poly(alkylene glycol) (meth)acrylates, i.e. short chains Bisomers, 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) in a mixture of water/ethanol as solvent. These hydrogels were characterized in terms...

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Bibliographic Details
Published in:Polymer bulletin (Berlin, Germany) Germany), 2006-09, Vol.57 (5), p.691-702
Main Authors: TOMIC, Simonida Lj, SULJOVRUJIC, Edin H, FILIPOVIC, Jovanka M
Format: Article
Language:English
Subjects:
Acrylates
Applied sciences
Biocompatibility
Buffer solutions
Copolymerization
Drug carriers
Ethanol
Exact sciences and technology
Hydrogels
Itaconic acid
Mechanical properties
Morphology
Organic polymers
Physicochemistry of polymers
Polyhydroxyethyl methacrylate
Properties and characterization
Solution and gel properties
Swelling
Thermodynamic properties
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Summary:SummaryNovel poly(Bisomer/HEMA/IA) hydrogels were prepared by radical copolymerization of poly(alkylene glycol) (meth)acrylates, i.e. short chains Bisomers, 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) in a mixture of water/ethanol as solvent. These hydrogels were characterized in terms of swelling in conditions similar to the biological fluids (pH range 2.20–7.40 buffer solutions), compression-strain measurements, thermal properties and morphology. The influence of the type of Bisomer and of the itaconic acid on swelling and mechanical properties, as well as on morphology and thermal behavior of the resulting hydrogels, were investigated.The in vitro study of biocompatibility, carried out with the hydrogels containing different types of Bisomers, showed no evidence of cell toxicity nor any considerable hemolytic activity. All hydrogels showed satisfactory bioadhesive properties, so these materials have potential as drug carriers or biological glue and sealants.
ISSN:0170-0839
1436-2449
DOI:10.1007/s00289-006-0606-3