Biocompatibility studies of HDPE–HA composites with different HA content

High-density polyethylene–hydroxyapatite (HDPE–HA) composites with different filler content (5–20 %) were synthesized by in situ ethylene polymerization. Good filler dispersion was observed without formation of agglomerates. Osteoblast cell behavior in HDPE–HA composites was evaluated in terms of ad...

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Bibliographic Details
Published in:Polymer bulletin (Berlin, Germany) Germany), 2015-12, Vol.72 (12), p.3083-3095
Main Authors: Hermán, Vanessa, González, Gema, Noris-Suárez, Karem, Albano, Carmen, Karam, Arquímedes, Romero, Karina, Yndriago, Laura, Marquez, Ana, Lozada, Lisbeth
Format: Article
Language:English
Subjects:
Alkaline phosphatase
Biocompatibility
Biological activity
Biomedical materials
Cell adhesion
Cell growth
Characterization and Evaluation of Materials
Chemistry
Complex Fluids and Microfluidics
Composite materials
Ethanol
Fillers
High density polyethylenes
Hydroxyapatite
Mechanical properties
Morphology
Nanocomposites
Nanoparticles
Organic Chemistry
Original Paper
Phosphatase
Phosphate esters
Physical Chemistry
Polymer Sciences
Polymerization
Polymers
Scanning electron microscopy
Soft and Granular Matter
Temperature
Transplants & implants
Variance analysis
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Summary:High-density polyethylene–hydroxyapatite (HDPE–HA) composites with different filler content (5–20 %) were synthesized by in situ ethylene polymerization. Good filler dispersion was observed without formation of agglomerates. Osteoblast cell behavior in HDPE–HA composites was evaluated in terms of adhesion, alkaline phosphatase activity and proliferation. Fluorescence and scanning electron microscopy results showed good cell adhesion and proliferation, and extensive filopodium-like protrusion connected to hydroxyapatite particles.
ISSN:0170-0839
1436-2449
DOI:10.1007/s00289-015-1454-9