Highly sensitive folic acid colorimetric sensor enabled by free-standing molecularly imprinted photonic hydrogels

Folic acid is an important biological compound for human disease diagnosis. Traditional detection methods of folic acid are mostly time-consuming or dependent on analytical equipment. Here we demonstrate the rapid and colorimetric detection of folic acid using a novel colorimetric sensor enabled by...

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Bibliographic Details
Published in:Polymer bulletin (Berlin, Germany) Germany), 2022-03, Vol.79 (3), p.1857-1871
Main Authors: Yang, Zhaokun, Gong, Fanghong, Yu, Zhangyong, Shi, Dongjian, Liu, Shirong, Chen, Mingqing
Format: Article
Language:English
Subjects:
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Chromatography
Colorimetry
Complex Fluids and Microfluidics
Emulsion polymerization
Enzymes
Folic acid
Hydrogels
Organic Chemistry
Original Paper
Photonics
Physical Chemistry
Polymer Sciences
Polymers
Polystyrene resins
Prepolymers
Proteins
Radiation
Recognition
Scanning electron microscopy
Sensors
Soft and Granular Matter
Vacuum distillation
Vitamin B
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Summary:Folic acid is an important biological compound for human disease diagnosis. Traditional detection methods of folic acid are mostly time-consuming or dependent on analytical equipment. Here we demonstrate the rapid and colorimetric detection of folic acid using a novel colorimetric sensor enabled by molecularly imprinted photonic hydrogels, which are prepared by the polymerization of precursor solution in the interstitial voids of the polystyrene colloidal crystal and subsequent removal of colloidal crystal and folic acid molecules. As folic acid is instable under the preparation process of molecularly imprinted photonic hydrogels, we introduce folic acid (imprinted molecule) in the form of supramolecular complex with β -CD units to improve its stability and further create stable molecular recognition sites. The folic acid recognition can be directly transferred into a visually perceptible color change due to the highly ordered macroporous structure. With this novel sensory system, the highly selective, high sensitive (as low as 10 –12  M), and rapid response (
ISSN:0170-0839
1436-2449
DOI:10.1007/s00289-021-03584-2