Modification of electrospun PVA/PAA scaffolds by cold atmospheric plasma: alignment, antibacterial activity, and biocompatibility

The ongoing search for better antibacterial wound care dressings has led to the design and fabrication of advanced functional nanomaterials. Taking advantage of electrospinning and cold atmospheric plasma (CAP), free-standing nanofibrous scaffolds are promising for use in novel biomedical applicatio...

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Bibliographic Details
Published in:Polymer bulletin (Berlin, Germany) Germany), 2019-02, Vol.76 (2), p.797-812
Main Authors: Arik, Nehir, Inan, Alper, Ibis, Fatma, Demirci, Emine A., Karaman, Ozan, Ercan, Utku K., Horzum, Nesrin
Format: Article
Language:English
Subjects:
Acids
Alignment
Antimicrobial agents
Biocompatibility
Biomedical materials
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Complex Fluids and Microfluidics
E coli
Electrodes
Electrospinning
Functional materials
Microorganisms
Morphology
Nanofibers
Nanomaterials
Nanoparticles
Organic Chemistry
Original Paper
Physical Chemistry
Plasma
Polyacrylic acid
Polymer Sciences
Polymers
Polyvinyl alcohol
Scaffolds
Soft and Granular Matter
Surface properties
Tissue engineering
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Summary:The ongoing search for better antibacterial wound care dressings has led to the design and fabrication of advanced functional nanomaterials. Taking advantage of electrospinning and cold atmospheric plasma (CAP), free-standing nanofibrous scaffolds are promising for use in novel biomedical applications. Random and aligned polyvinyl alcohol (PVA)/polyacrylic acid (PAA) nanofiber scaffolds are fabricated by electrospinning and treated with CAP. In this study, we investigate the effects of CAP treatment on alignment, hydrophilicity, antibacterial activity, and biocompatibility in determining the surface properties of the nanofibrous scaffolds. The results of vibrational polarization spectroscopy analysis indicate that CAP treatment changes the degree of alignment of the nanofibers. Furthermore, both random and aligned CAP-treated nanofibrous scaffolds show significant antibacterial activity against the E. coli strain. The results of an in vitro scratch assay reveal that CAP treatment of PVA/PAA nanofibers has no toxic effect.
ISSN:0170-0839
1436-2449
DOI:10.1007/s00289-018-2409-8