Local structure is critical for superoxide dismutase activity in copper complexes: Relationship between EPR parameters, structure and activity in some sterically hindered copper(II) bis(hydrazono-triazine) complexes

Electron paramagnetic resonance (EPR) spectrometry and molecular mechanics force field calculations have been performed on some sterically hindered copper(II) complexes with hydrazonotriazine ligands, in order to gain further insight into the relationship between their bonding, structures and biolog...

Full description

Saved in:
Bibliographic Details
Published in:Applied magnetic resonance 2003-03, Vol.25 (1), p.13-28
Main Authors: Goodman, B. A., Palivan, C. G., Palivan, H., Tomas, S.
Format: Article
Language:English
Subjects:
Biological activity
Copper
Copper compounds
Electron paramagnetic resonance
Oxygen atoms
Planar structures
Scavenging
Superoxide dismutase
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Electron paramagnetic resonance (EPR) spectrometry and molecular mechanics force field calculations have been performed on some sterically hindered copper(II) complexes with hydrazonotriazine ligands, in order to gain further insight into the relationship between their bonding, structures and biological activity. As was the case with Cu(II) bis(hydrazono-triazine) complexes studied previously, the most stable configuration for all of the complexes involves coordination of two nitrogen and two oxygen atoms (2N2O) in a distorted tetragonal arrangement. With the present complexes, however, the superoxide radical scavenging activities were very low, a result which may be explained by their inability to form a (nearly) square planar structure, which facilitates the copper redox cycling during superoxide dismutation.
ISSN:0937-9347
1613-7507
DOI:10.1007/BF03166963