Grafted poly (vinyl alcohol) functionalized by folic acid and its transdermal microneedles

• Published in: Polymer bulletin (Berlin, Germany) Germany), 2022-02, Vol.79 (2), p.867-882
• Main Authors: Liu, Weijun, Guo, Wenjing, Yang, Mei, Zhang, Xiaoduo, Wu, Fanhong
• Format: Article
• Language: English
• Subjects: Acids; Alcohol; Cellulose; Characterization and Evaluation of Materials; Chemistry; Chemistry and Materials Science; Complex Fluids and Microfluidics; Composite materials; Folic acid; Grafting; High temperature; Hydrogels; Insulin; Needles; NMR; Nuclear magnetic resonance; Organic Chemistry; Original Paper; Physical Chemistry; Polymer Sciences; Polymers; Soft and Granular Matter; Transdermal medication; Vitamin B; X ray photoelectron spectroscopy
• ISSN: 0170-0839; 1436-2449
• DOI: 10.1007/s00289-021-03535-x

A well-soluble grafted polymer of poly (vinyl alcohol) (PVA) used to fabricate dissolved microneedles was achieved through classic Michael addition and the functionalization of folate-targeted ligand. FTIR, Raman spectrum and 1 H-NMR characterization ascertained the microstructure of resulted polymer. XPS analysis further confirmed the reasonability of analytic structure as well as the functionalized rate of folate of the modified PVA. Using the synthetic polymer to fabricate microneedles patch which was only a matter of 10% (w/w) concentration could accomplish, and the gained patch displayed decent insertion capability of porcine cadaver skin and the inserted microneedles emerged obviously a dissolved phenomenon within 1 min. Meanwhile, the left traces on surface of the skin recovered about 15 min after the patch removal, implying a little invasiveness to skin. The release of insulin-loaded microneedles exhibited burst release in the initial phase and then reduced gradually, and the insulin loaded in the needles of patch might release totally within 1 h, revealing the functionalized grafted polymer could be used as a well material for fabrication dissolving microneedles.