Visualization of Digestion Process Using 19F MRI

Tracing parameters of digestion process could help in setting more accurate diagnosis for patients with gastrointestinal diseases. For this purpose, we suggest a new type of food tracer. By soaking liquid perfluorocarbon in dry rodent food, each step of digestion process can be visualized on 19 F-ma...

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Bibliographic Details
Published in:Applied magnetic resonance 2018, Vol.49 (1), p.71-75
Main Authors: Volkov, Dmitry V., Gulyaev, Mikhail V., Kosenkov, Alexey V., Silachev, Denis N., Anisimov, Nikolay V., Chernyaev, Alexander P., Pirogov, Yury A.
Format: Article
Language:English
Subjects:
Abdomen
Atoms and Molecules in Strong Fields
Contrast agents
Digestion
Experiments
Fluorine
Food
Gastrointestinal system
Image contrast
Ionizing radiation
Laboratory animals
Laser Matter Interaction
Magnetic resonance imaging
Medical imaging
NMR
Nuclear magnetic resonance
Organic Chemistry
Original Paper
Perfluorocarbons
Physical Chemistry
Physics
Physics and Astronomy
Physiology
Process management
Radiation
Rodents
Small intestine
Solid State Physics
Spectroscopy/Spectrometry
Stomach
Visualization
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Summary:Tracing parameters of digestion process could help in setting more accurate diagnosis for patients with gastrointestinal diseases. For this purpose, we suggest a new type of food tracer. By soaking liquid perfluorocarbon in dry rodent food, each step of digestion process can be visualized on 19 F-magnetic resonance (MR) images. Compared with liquid contrast agents, food is able to fill organs of gastrointestinal tract more tightly and yield properties of digestion process. However, rats, participating in such study, should be set on a water diet before experiment. 19 F-MR images are obtained with volume scanning (3D) pulse sequence based on multiple spin echo methodic with minimal time intervals between echoes. Gastrointestinal 19 F-magnetic resonance imaging (MRI) visualization is a harmless real-time tracking method which could be easily transferred into clinical practice. Moreover, it does not apply ionizing radiation, so in the combination with reference 1 H-MRI this method could become very useful in treatment process assessment.
ISSN:0937-9347
1613-7507
DOI:10.1007/s00723-017-0934-5