Research into Dinitrosyl Iron Complexes in Living Organisms Through EPR as an Example of Applying this Method in Biology: A Review

This review discusses the successful application of EPR method to investigating dinitrosyl iron complexes (DNICs) with thiol-containing ligands, being currently considered a ‘working form’ of nitrogen monoxide (NO) as an universal regulator of a wide range of metabolic processes in almost all living...

Full description

Saved in:
Bibliographic Details
Published in:Applied magnetic resonance 2023-02, Vol.54 (2), p.289-309
Main Author: Vanin, Anatoly F.
Format: Article
Language:English
Subjects:
Atoms and Molecules in Strong Fields
Chemical elements
Free radicals
Iron
Laser Matter Interaction
Ligands
Mitochondria
Nitric oxide
Organic Chemistry
Organisms
Physical Chemistry
Physics
Physics and Astronomy
Proteins
Review
Solid State Physics
Spectroscopy/Spectrometry
Sulfur
Temperature
Yeast
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This review discusses the successful application of EPR method to investigating dinitrosyl iron complexes (DNICs) with thiol-containing ligands, being currently considered a ‘working form’ of nitrogen monoxide (NO) as an universal regulator of a wide range of metabolic processes in almost all living organisms. EPR method made it possible not only to discover these complexes in living organisms due to the EPR signal with g av.  = 2.03 signal, characteristic of the mononuclear form of DNICs, but also to identify these complexes as DNICs with thiol-containing ligands (using only this method). Finally, using the EPR method (together with other experimental approaches), a mechanism for synthesizing these complexes was put forward. This mechanism shows that DNICs with thiol-containing ligands can be donors of both nitrogen monoxide and nitrosonium cations (NO + ) in living organisms.
ISSN:0937-9347
1613-7507
DOI:10.1007/s00723-022-01518-3