Semi-supervised model applied to the prediction of the response to preoperative chemotherapy for breast cancer

Breast cancer is the second most frequent one, and the first one affecting the women. The standard treatment has three main stages: a preoperative chemotherapy followed by a surgery operation, then an post-operatory chemotherapy. Because the response to the preoperative chemotherapy is correlated to...

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Bibliographic Details
Published in:Soft computing (Berlin, Germany) Germany), 2011-06, Vol.15 (6), p.1137-1144
Main Authors: Coelho, Frederico, Braga, Antônio de Pádua, Natowicz, René, Rouzier, Roman
Format: Article
Language:English
Subjects:
Algorithms
Artificial Intelligence
Breast cancer
Cancer therapies
Chemotherapy
Clinical trials
Computational Intelligence
Control
Datasets
Engineering
Focus
Gene expression
Machine learning
Mathematical Logic and Foundations
Mechatronics
Neural networks
Patients
Robotics
Semi-supervised learning
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Summary:Breast cancer is the second most frequent one, and the first one affecting the women. The standard treatment has three main stages: a preoperative chemotherapy followed by a surgery operation, then an post-operatory chemotherapy. Because the response to the preoperative chemotherapy is correlated to a good prognosis, and because the clinical and biological information do not yield to efficient predictions of the response, a lot of research effort is being devoted to the design of predictors relying on the measurement of genes’ expression levels. In the present paper, we report our works for designing genomic predictors of the response to the preoperative chemotherapy, making use of a semi-supervised machine learning approach. The method is based on margin geometric information of patterns of low density areas, computed on a labeled dataset and on an unlabeled one.
ISSN:1432-7643
1433-7479
DOI:10.1007/s00500-010-0589-8