Electrospinning of polyvinylalcohol–polycaprolactone composite scaffolds for tissue engineering applications

Random nanofibrous composite scaffolds of PVA/PCL bilayer were fabricated by electrospinning method. The bilayer nanofibrous scaffolds were subjected to detailed structural, morphological, chemical, and thermal analysis using XRD, SEM, FTIR, and DSC. Morphological investigations revealed that the pr...

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Bibliographic Details
Published in:Polymer bulletin (Berlin, Germany) Germany), 2013-11, Vol.70 (11), p.2995-3010
Main Authors: Maheshwari, Subramanian Uma, Kumar, Samuel Vasanth, Nagiah, Naveen, Uma, Tiruchirapally Sivagnanam
Format: Article
Language:English
Subjects:
Adhesion
Applied sciences
Bilayers
Biocompatibility
Biological and medical sciences
Bone marrow
Cell adhesion & migration
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Complex Fluids and Microfluidics
Exact sciences and technology
Fibers and threads
Forms of application and semi-finished materials
Fourier transforms
Investigations
Mechanical properties
Medical sciences
Membranes
Morphology
Nanoparticles
Organic Chemistry
Original Paper
Physical Chemistry
Polycaprolactone
Polyesters
Polymer industry, paints, wood
Polymer Sciences
Polymers
Polyvinyl alcohol
Scaffolds
Soft and Granular Matter
Solvents
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Technology of polymers
Technology. Biomaterials. Equipments
Thermal analysis
Tissue engineering
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Summary:Random nanofibrous composite scaffolds of PVA/PCL bilayer were fabricated by electrospinning method. The bilayer nanofibrous scaffolds were subjected to detailed structural, morphological, chemical, and thermal analysis using XRD, SEM, FTIR, and DSC. Morphological investigations revealed that the prepared nanofibers have uniform morphology and the average fiber diameters for bilayer samples A, B, and C are 203, 252, and 244 nm, respectively. The obtained scaffolds have a porous structure with porosity of 77, 89.2, and 78.3 % for bilayer samples A, B, and C, respectively. FTIR analysis ensured complete evaporation of solvent and formation of non-interactive bilayers. Biocompatibility of the membranes was investigated by studying the adhesion of mouse NIH 3T3 fibroblasts for 72 h, and its enhanced adhesion and proliferation proved its mettle as a potential scaffold for tissue engineering applications.
ISSN:0170-0839
1436-2449
DOI:10.1007/s00289-013-1002-4