Facile synthesis of three-dimensional porous hydrogel and its evaluation

The aim of the current research work was to fabricate polymeric nexus for controlled delivery of metoprolol tartrate by using free radical polymerization. Polymer (aloe vera, sodium carboxymethyl cellulose, and meggletose) was crosslinked with monomer (acrylic acid) by using N,N methylene bisacrylam...

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Bibliographic Details
Published in:Polymer bulletin (Berlin, Germany) Germany), 2022-09, Vol.79 (9), p.7407-7428
Main Authors: Danish, Zeeshan, Ijaz, Hira, Razzaque, Ghulam, Haq, Nauman ul, Aslam, Muhammad Mahran
Format: Article
Language:English
Subjects:
Acrylic acid
Carboxymethyl cellulose
Cellulose
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Complex Fluids and Microfluidics
Crosslinking
Electron microscopes
Equilibrium
Fourier transforms
Free radical polymerization
Free radicals
Hydrogels
Infrared spectroscopy
Lactose
Methylene bisacrylamide
Monomers
Organic Chemistry
Original Paper
Physical Chemistry
Polymer Sciences
Polymers
Pore size
Potassium
Scanning electron microscopy
Sodium carboxymethyl cellulose
Soft and Granular Matter
Sol-gel processes
Swelling
Tensile strength
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Summary:The aim of the current research work was to fabricate polymeric nexus for controlled delivery of metoprolol tartrate by using free radical polymerization. Polymer (aloe vera, sodium carboxymethyl cellulose, and meggletose) was crosslinked with monomer (acrylic acid) by using N,N methylene bisacrylamide. Swelling behavior was studied in pH 1.2 and 7.4. Sol gel fraction depicted gel fraction increased with the increase in feed ratio (polymer, monomer, and crosslinker). Optimized formulation was evaluated via Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). FTIR confirmed compatibility of metoprolol with formulated system. Moreover, pH-dependent swelling was observed, experiencing significant swelling at higher pH. SEM depicted porous architecture which is responsible for swelling, drug loading, and release. Dissolution studies showed percentage drug release was significant in pH 7.4. Hence, the current research work demonstrates sustained delivery of metoprolol by employing varying concentration of polymer, monomer, and crosslinker. These fascinating properties made hydrogel a promising carrier for sustained drug delivery. Graphic abstract
ISSN:0170-0839
1436-2449
DOI:10.1007/s00289-021-03855-y