Biocompatible and antimicrobial carboxymethyl xanthan/zinc physical hydrogels

Due to the superior properties of physical hydrogels especially those that originated from biodegradable polymers, carboxymethyl xanthan (CMX) was prepared, and physically gelled with zinc ions. The chemical structures of CMX and its hydrogels were verified by FTIR and 1 H NMR. The porous structure...

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Bibliographic Details
Published in:Polymer bulletin (Berlin, Germany) Germany), 2022-05, Vol.79 (5), p.3219-3231
Main Authors: Abdel Aziz, M. S., Salama, H. E.
Format: Article
Language:English
Subjects:
Antimicrobial agents
Bacteria
Biocompatibility
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Complex Fluids and Microfluidics
Electron microscopes
Ethanol
Gram-negative bacteria
Gram-positive bacteria
Hydrogels
Hydrogen bonds
Microorganisms
NMR
Nuclear magnetic resonance
Organic Chemistry
Original Paper
Physical Chemistry
Physical properties
Polymer Sciences
Radiation
Research parks
Soft and Granular Matter
Stability analysis
Thermal stability
Thermogravimetric analysis
Toxicity
Vibration
Xanthan
Zinc
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Summary:Due to the superior properties of physical hydrogels especially those that originated from biodegradable polymers, carboxymethyl xanthan (CMX) was prepared, and physically gelled with zinc ions. The chemical structures of CMX and its hydrogels were verified by FTIR and 1 H NMR. The porous structure of hydrogels was verified using scanning electron microscopy, while the energy-dispersive X-ray spectroscopy (EDX) confirmed the presence of Zn in hydrogels. The effect of Zn ions on the crystalline structure was studied using wide-angle X-ray diffraction. Thermogravimetric analysis indicated enhanced thermal stability upon increasing the Zn ions content. Cytotoxicity assays confirmed the non-toxicity of hydrogels against the MCF-7 breast cells. The microbial inhibition of both Gram-positive and Gram-negative bacteria was significantly improved by increasing the content of Zn 2+ in hydrogels. The extracted data confirmed the competency of the prepared hydrogels in drug delivery fields due to their non-toxicity, antibacterial activity and enhanced physical properties.
ISSN:0170-0839
1436-2449
DOI:10.1007/s00289-021-03668-z