Analysis of Cerebral Hemodynamics in Healthy Adult Rhesus with Dynamic Susceptibility Contrast Perfusion (DSC-MR) Imaging

• Published in: Applied magnetic resonance 2016-04, Vol.47 (4), p.387-394
• Main Authors: Zhao, Xin-xiang, Pu, Jun, He, Li-ping, Yang, Fei-fei, Yang, Nan
• Format: Article
• Language: English
• Subjects: Atoms and Molecules in Strong Fields; Bandwidths; Blood; Blood flow; Blood volume; Brain research; Cerebral cortex; Contrast agents; Correlation coefficients; Cytotoxicity; Edema; Hemodynamics; Hypothermia; Hypoxia; Ischemia; Laboratory animals; Laser Matter Interaction; Magnetic resonance imaging; Organic Chemistry; Physical Chemistry; Physics; Physics and Astronomy; Physiology; Respiration; Software; Solid State Physics; Spectroscopy/Spectrometry; Thalamus; Variance analysis
• ISSN: 0937-9347; 1613-7507
• DOI: 10.1007/s00723-016-0763-y

The aim of this study was to investigate hemodynamic differences in different brain regions of normal macaque brains using dynamic susceptibility contrast (DSC) perfusion magnetic resonance (MR) imaging. Twelve male subjects were selected for DSC perfusion MR imaging (age 4–8 years). The relative cerebral blood volume (rCBV) and relative cerebral blood flow (rCBF) images were obtained by post-processing software. The values of rCBV and rCBF were recorded from the frontal cortex, parietal cortex, occipital cortex, head of caudate nucleus, posterior limb of internal capsule, thalamus, midbrain, pons, cerebellar, semioval area and splenium of the corpus callosum. The figures of rCBV and rCBF can clearly demonstrate the hemodynamic differences in various cerebral parts. It has been noted that rCBV and rCBF values have no significant difference between the right and left hemisphere ( P  > 0.05). The values of rCBF from cerebral cortex were significantly higher than that of white matter ( P