The Influence of Pressure in Paracetamol Tablet Compaction on 14N Nuclear Quadrupole Resonance Signal

14 N nuclear quadrupole resonance ( 14 N NQR) of several commercially available paracetamol tablets was measured. The spectra of two polymorphs are presented. The linewidths of the correspondent 14 N NQR lines in all the measured samples containing the room-temperature stable monoclinic polymorph we...

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Bibliographic Details
Published in:Applied magnetic resonance 2013-06, Vol.44 (6), p.735-743
Main Authors: Lužnik, J., Pirnat, J., Jazbinšek, V., Lavrič, Z., Srčič, S., Trontelj, Z.
Format: Article
Language:English
Subjects:
Analgesics
Atoms and Molecules in Strong Fields
Counterfeiting
Electric fields
Laser Matter Interaction
Manufacturers
Nitrogen
Nuclear quadrupole resonance
Organic Chemistry
Physical Chemistry
Physics
Physics and Astronomy
Quadrupoles
Room temperature
Signal to noise ratio
Solid State Physics
Spectroscopy/Spectrometry
Spectrum analysis
Tablets
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Description
Summary:14 N nuclear quadrupole resonance ( 14 N NQR) of several commercially available paracetamol tablets was measured. The spectra of two polymorphs are presented. The linewidths of the correspondent 14 N NQR lines in all the measured samples containing the room-temperature stable monoclinic polymorph were noticeably different. We proved experimentally that the linewidth differences are the consequence of different compacting pressure in the production of tablets.
ISSN:0937-9347
1613-7507
DOI:10.1007/s00723-013-0440-3