Chitosan as a matrix for grafting methyl methacrylate: synthesis, characterization and evaluation of grafts for biomedical applications

This study intends to investigate the potentials of chitosan- g -PMMA [poly(methyl methacrylate)] graft copolymers in corneal tissue engineering. The polymerization reaction between chitosan and methyl methacrylate (MMA) was standardized by varying temperature, pH, initiator and monomer concentratio...

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Bibliographic Details
Published in:Polymer bulletin (Berlin, Germany) Germany), 2016-11, Vol.73 (11), p.3105-3117
Main Authors: Hemalatha, Thiagarajan, Yadav, Shachi, Krithiga, Gunasekaran, Sastry, Thotapalli P.
Format: Article
Language:English
Subjects:
Biocompatibility
Biomedical materials
Biopolymers
Characterization and Evaluation of Materials
Chemistry
Chemistry and Materials Science
Chitosan
Complex Fluids and Microfluidics
Cornea
Epithelium
Fourier transforms
Graft copolymers
Lysozyme
Mechanical properties
Monomers
Organic Chemistry
Original Paper
Physical Chemistry
Polymer Sciences
Polymerization
Polymethyl methacrylate
Potassium
Potassium persulfate
Scanning electron microscopy
Sodium metabisulfite
Soft and Granular Matter
Spectrum analysis
Thermal stability
Tissue engineering
Transplants & implants
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Summary:This study intends to investigate the potentials of chitosan- g -PMMA [poly(methyl methacrylate)] graft copolymers in corneal tissue engineering. The polymerization reaction between chitosan and methyl methacrylate (MMA) was standardized by varying temperature, pH, initiator and monomer concentrations. 113 % grafting yield was obtained at 60 °C, pH 6, 2.1 × 10 −3 mol/L of sodium metabisulfite and 1.48 × 10 −3 mol/L of potassium persulphate and 1.99 × 10 −4 mol/L of monomer concentration. Fourier transform infrared spectroscopy confirmed the grafting of PMMA onto chitosan. The grafts possessed better thermal stability compared to chitosan films. The rough-surfaced (as evidenced by scanning electron microscopy) grafts were able to degrade under in vitro conditions in presence of lysozyme. The grafts exhibited 88 % optical clarity and also supported the proliferation of human corneal epithelial cell line. The above results indicate the potentials of chitosan- g -PMMA and its possible use in corneal tissue engineering applications.
ISSN:0170-0839
1436-2449
DOI:10.1007/s00289-016-1644-0