Plasma Dynamic Viscosity Determined by NMR

A nuclear magnetic resonance (NMR) based experimental procedure to determine the dynamic viscosity ( η ) in blood plasma solutions is presented. An equation relating η and the transverse proton magnetic relaxation rate ( 1 / T 2 ) is obtained after considering plasma an extremely diluted water solut...

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Bibliographic Details
Published in:Applied magnetic resonance 2018-10, Vol.49 (10), p.1075-1083
Main Authors: Guevara, Manuel Arsenio Lores, Torres, Yulianela Mengana, Naranjo, Juan C. García, Suárez, Norberto Rodríguez, Beyries, Lidia C. Suárez, Feliu, María A. Marichal, Boada, Teresa Simón, Reyes, Inocente C. Rodríguez, Philippé, Jan
Format: Article
Language:English
Subjects:
Atoms and Molecules in Strong Fields
Blood plasma
Calibration
Hemoglobin
Laser Matter Interaction
Macromolecules
Magnetic fields
Magnetic induction
Magnetic relaxation
Multiple myeloma
NMR
Nuclear magnetic resonance
Organic Chemistry
Original Paper
Ostwald ripening
Physical Chemistry
Physics
Physics and Astronomy
Plasma
Proteins
Protons
Relaxation time
Samples
Solid State Physics
Spectroscopy/Spectrometry
Statistical analysis
Viscometers
Viscosity
Water chemistry
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Summary:A nuclear magnetic resonance (NMR) based experimental procedure to determine the dynamic viscosity ( η ) in blood plasma solutions is presented. An equation relating η and the transverse proton magnetic relaxation rate ( 1 / T 2 ) is obtained after considering plasma an extremely diluted water solution of albumin with no long range hydrodynamics interactions among macromolecules, and a fast exchange of water molecules between the free and associated water. Carr–Purcell–Meiboom–Gill pulse sequence was used to measure the transverse proton magnetic relaxation time ( T 2 ) in a magnetic resonance console coupled to one homogeneous magnetic system (0.095 T). A η value of 1.68 ± 0.08 mPa s was obtained in 20 control samples, which statistically matched the value obtained in the same samples using an Ostwald viscometer (1.61 ± 0.04 mPa s). η was determined in 172 patients with multiple myeloma (2.47 ± 0.15 mPa s) and 72 with sickle cell disease (2.45 ± 0.24 mPa s) showing a statistically significant increase over the control individuals. The results show the utility of this NMR method to estimate dynamic viscosity in plasma for medical purposes, and a comparison with other methods is done.
ISSN:0937-9347
1613-7507
DOI:10.1007/s00723-018-1026-x