Changes of Nitric Oxide Content in the Rat Hippocampus, Heart and Liver in Acute Phase of Ischemia

Electron paramagnetic resonance (EPR) was used as a method to record nitric oxide (NO) production in the tissues of the brain, heart and liver of healthy rats, and rats after modeling of ischemic stroke. Direct measurement of the dynamics of NO production by EPR spectroscopy in our experiments showe...

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Bibliographic Details
Published in:Applied magnetic resonance 2016-09, Vol.47 (9), p.965-976
Main Authors: Andrianov, V. V., Pashkevich, S. G., Yafarova, G. G., Denisov, A. A., Iyudin, V. S., Bogodvid, T. Kh, Dosina, M. O., Kulchitsky, V. A., Gainutdinov, Kh. L.
Format: Article
Language:English
Subjects:
Atoms and Molecules in Strong Fields
Brain
Electron paramagnetic resonance
Heart
Hippocampus
Hypoxia
Ischemia
Laboratory animals
Laser Matter Interaction
Liver
Metabolism
Modelling
Nitric oxide
Organic Chemistry
Pathogenesis
Physical Chemistry
Physics
Physics and Astronomy
Solid State Physics
Spectroscopy/Spectrometry
Spectrum analysis
Stroke
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Summary:Electron paramagnetic resonance (EPR) was used as a method to record nitric oxide (NO) production in the tissues of the brain, heart and liver of healthy rats, and rats after modeling of ischemic stroke. Direct measurement of the dynamics of NO production by EPR spectroscopy in our experiments showed that after the emergence of signs of ischemic stroke, 5 h after the start of ischemia, the content of NO in the hippocampus decreased two- to threefold and this decrease was maintained at 24 and 72 h. Deserving special attention is the data demonstrating that there is a greater decrease of NO production in the tissues of the heart and liver than in the brain. Consequently, the change in intensity of NO production in the modeling of ischemic events in the brain has a systemic, not a local character.
ISSN:0937-9347
1613-7507
DOI:10.1007/s00723-016-0815-3