A Method for Fluorescent Diagnosis of Malignant Cutaneous Neoplasms Using Ytterbium Phthalocyanines

WHO data indicate that malignant neoplasms of the skin are the most common type of cancer, accounting for up to a third of all cases. Despite the successful treatment of this type of pathology, the increases in the incidence of skin cancer which have been continuously recorded over past decades make...

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Bibliographic Details
Published in:Biomedical engineering 2022-11, Vol.56 (4), p.237-241
Main Authors: Stavtsev, D. D., Dubinina, T. V., Gorbunova, E. A., Gerasimenko, A. Yu
Format: Article
Language:English
Subjects:
Alcohol
Analysis
Biomaterials
Biomedical and Life Sciences
Biomedicine
Cancer
Cancer therapies
Care and treatment
Chlorine
Diagnosis
Engineering
Fluorescence
Lasers
Melanoma
Methods
Neoplasms
Photodynamic therapy
Phthalocyanins
Radiation
Skin
Skin cancer
Spectrum analysis
Substitutes
Tissues
Tumors
Ytterbium
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Summary:WHO data indicate that malignant neoplasms of the skin are the most common type of cancer, accounting for up to a third of all cases. Despite the successful treatment of this type of pathology, the increases in the incidence of skin cancer which have been continuously recorded over past decades make the development of new diagnostic methods relevant. A potential solution to this problem may be provided by use of fluorescent diagnostics combined with formulations based on ytterbium complexes of phthalocyanines. New chlorine-substituted ytterbium phthalocyanines – ytterbium (III) hexadecachlorophthalocyaninate and octa(p-chlorophenoxy)-substituted ytterbium (III) phthalocyanine – were prepared and their spectral properties were investigated in the visible and near-IR spectral regions. Octa(p-chlorophenoxy)-substituted ytterbium (III) phthalocyanine was found to give a higher fluorescence yield in the IR region, which makes its use preferable as a photosensitizer in the diagnosis of malignant skin tumors.
ISSN:0006-3398
1573-8256
DOI:10.1007/s10527-022-10210-6