An Automated Method for Blood Type Determination by Red Blood Cell Agglutination Assay

A new automated method for assaying specific agglutination of red blood cells upon addition of monoclonal antibodies to whole blood test samples is presented. The method can be used for blood type determination. The method is based on lying drop photometry of blood samples with added Tsoliclone mono...

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Bibliographic Details
Published in:Biomedical engineering 2022, Vol.55 (5), p.328-332
Main Authors: Aristov, A. A., Rozenbaum, Yu. A., Evtushenko, G. S.
Format: Article
Language:English
Subjects:
Agglutination
Analysis
Antigens
Automation
Biomaterials
Biomedical and Life Sciences
Biomedicine
Blood
Blood groups
Blood transfusion
Cell agglutination
Engineering
Erythrocytes
Medical examination
Methods
Monoclonal antibodies
Photometry
Portable equipment
Reagents
Sensors
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Summary:A new automated method for assaying specific agglutination of red blood cells upon addition of monoclonal antibodies to whole blood test samples is presented. The method can be used for blood type determination. The method is based on lying drop photometry of blood samples with added Tsoliclone monoclonal antibodies. Mechanical vibration of drop samples promotes better cell agglutination and redistribution through the volume of the sample. Experimental studies revealed significant differences in photometric values for samples with and without agglutination. This method may provide the basis for developing a portable automatic blood-typing device.
ISSN:0006-3398
1573-8256
DOI:10.1007/s10527-022-10129-y