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An Automated Method for Blood Type Determination by Red Blood Cell Agglutination Assay
A new automated method for assaying specific agglutination of red blood cells upon addition of monoclonal antibodies to whole blood test samples is presented. The method can be used for blood type determination. The method is based on lying drop photometry of blood samples with added Tsoliclone mono...
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Published in: | Biomedical engineering 2022, Vol.55 (5), p.328-332 |
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creator | Aristov, A. A. Rozenbaum, Yu. A. Evtushenko, G. S. |
description | A new automated method for assaying specific agglutination of red blood cells upon addition of monoclonal antibodies to whole blood test samples is presented. The method can be used for blood type determination. The method is based on lying drop photometry of blood samples with added Tsoliclone monoclonal antibodies. Mechanical vibration of drop samples promotes better cell agglutination and redistribution through the volume of the sample. Experimental studies revealed significant differences in photometric values for samples with and without agglutination. This method may provide the basis for developing a portable automatic blood-typing device. |
doi_str_mv | 10.1007/s10527-022-10129-y |
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subjects | Agglutination Analysis Antigens Automation Biomaterials Biomedical and Life Sciences Biomedicine Blood Blood groups Blood transfusion Cell agglutination Engineering Erythrocytes Medical examination Methods Monoclonal antibodies Photometry Portable equipment Reagents Sensors |
title | An Automated Method for Blood Type Determination by Red Blood Cell Agglutination Assay |
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