Carboxylated Chalcone and Benzaldehyde Derivatives of Triosmium Carbonyl Clusters: Synthesis, Characterization and Biological Activity Towards MCF-7 Cells

The activated cluster Os 3 (CO) 10 (CH 3 CN) 2 ( 1 ) reacts readily with a number of carboxylated chalcones and benzaldehydes ( 2a − j ) to afford products with the general formula Os 3 (CO) 10 (µ-H)(µ-O 2 CR) ( 3a – j ). The structures of all the novel clusters have been characterized by IR and 1 H...

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Bibliographic Details
Published in:Journal of cluster science 2020-07, Vol.31 (4), p.759-767
Main Authors: Kwek, Zheng Hua, Ganguly, Rakesh, Afreen, A. Mohamed, Koh, Wei Xiang, Leong, Weng Kee, Tan, Yong Leng Kelvin
Format: Article
Language:English
Subjects:
Benzaldehyde
Biological activity
Breast cancer
Cancer
Carbonyls
Catalysis
Chemical analysis
Chemistry
Chemistry and Materials Science
Clusters
Cytotoxicity
Inorganic Chemistry
Ligands
Mass spectrometry
Nanochemistry
NMR spectroscopy
Original Paper
Physical Chemistry
Scientific imaging
Single crystals
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Summary:The activated cluster Os 3 (CO) 10 (CH 3 CN) 2 ( 1 ) reacts readily with a number of carboxylated chalcones and benzaldehydes ( 2a − j ) to afford products with the general formula Os 3 (CO) 10 (µ-H)(µ-O 2 CR) ( 3a – j ). The structures of all the novel clusters have been characterized by IR and 1 H NMR spectroscopy, as well as mass spectrometry and elemental analysis. Single-crystal X-ray diffraction analysis has also been carried out for one of the carboxylated chalcones and two of the derivatized clusters. The activity of some of the derivatized clusters against the ER+ breast carcinoma MCF-7 cancer cell line has also been evaluated.
ISSN:1040-7278
1572-8862
DOI:10.1007/s10876-019-01684-8