Antineoplastic Effect of PAC Capped Silver Nanoparticles Promote Apoptosis in HT-29 Human Colon Cancer Cells

Proanthocyanidin (PAC) is an anti-cancer drug that effectively treat various cancers, including colon cancer. Whereas, the chemotherapeutic potential has restricted to low bioavailability and more defects. To overcome these complications, PAC produces a selective intend of AgNPs as a medicine for ca...

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Bibliographic Details
Published in:Journal of cluster science 2019-03, Vol.30 (2), p.483-493
Main Authors: Mani, Suganya, Balasubramanian, Mythili Gnanamangai, Ponnusamy, Ponmurugan, Vijayan, Paranthaman
Format: Article
Language:English
Subjects:
Apoptosis
Aqueous solutions
Bioavailability
Cancer therapies
Catalysis
Cell death
Chemistry
Chemistry and Materials Science
Chemotherapy
Colorectal cancer
Cytotoxicity
Drug resistance
Fourier transforms
Hydroxyl groups
Inorganic Chemistry
Medicine
Morphology
Nanochemistry
Nanocomposites
Nanoparticles
Original Paper
Phenols
Physical Chemistry
Radiation
Scanning electron microscopy
Silver
Spectrum analysis
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Summary:Proanthocyanidin (PAC) is an anti-cancer drug that effectively treat various cancers, including colon cancer. Whereas, the chemotherapeutic potential has restricted to low bioavailability and more defects. To overcome these complications, PAC produces a selective intend of AgNPs as a medicine for cancer cells and growing modern antineoplastic promoter, an innovative nano-capped drug was enhanced bioavailability of tumor cells. The synthesized PAC-AgNPs was described by spectroscopy analysis. Phenolic compound has hydroxyl groups which are able to bind to metals and reduce the metal salt and provide stability against agglomeration was confirmed by FTIR and spherical or polygonal shape with an average size of 72.35 nm found through FE-SEM analysis, applicable for targeted delivery to specific tissues. The potential of this nano-incorporate drug had been caused apoptosis in colon cancer cells was measured. Significantly, it was found in decreasing cell growth by MTT assay, morphological changes such as membrane blebbing and chromatin condensation exhibited in AO/EB staining. At the end, the mitochondrial pathway of apoptotic cell death confirmed by cell cycle progression as well as annexin V/PI. These results strongly suggest that PAC-AgNPs could be used as a major nano-composite therapeutic drug for effectively treated with colon cancer.
ISSN:1040-7278
1572-8862
DOI:10.1007/s10876-019-01510-1