Synthesis of Biocompatible Zinc Oxide (ZnO) Nanoparticles and Their Neuroprotective Effect of 6-OHDA Induced Neural Damage in SH-SY 5Y Cells

Biocompatible zinc oxide nanoparticles were prepared using a simple co-precipitation method. Through this method, the synthesized zinc oxide nanoparticles that are of uniform size and highly crystalline in nature. The particle formation and stability were confirmed with UV–visible spectrometry and t...

Full description

Saved in:
Bibliographic Details
Published in:Journal of cluster science 2020-11, Vol.31 (6), p.1315-1328
Main Authors: Ding, Xiyan, Lin, Ke, Li, Yandong, Dang, Minyan, Jiang, Lijie
Format: Article
Language:English
Subjects:
Biocompatibility
Catalysis
Cell death
Chemistry
Chemistry and Materials Science
Damage
Disease
Fourier transforms
Functional groups
Infrared analysis
Inorganic Chemistry
Methods
Morphology
Nanochemistry
Nanomaterials
Nanoparticles
Nanotechnology
Nitrates
Nitric oxide
Original Paper
Particle size
Pathogenesis
Physical Chemistry
Spectrum analysis
Synthesis
Zinc oxide
Zinc oxides
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Biocompatible zinc oxide nanoparticles were prepared using a simple co-precipitation method. Through this method, the synthesized zinc oxide nanoparticles that are of uniform size and highly crystalline in nature. The particle formation and stability were confirmed with UV–visible spectrometry and the functional groups which present in the particles were identified with FT-IR analysis. The particle size was confirmed with DLS analysis and the charges of the particles were determined by Zeta analysis. Particle size and shape were depicted from SEM analysis. The characterized particles were highly effective against the 6-OHDA induced cell damage in SH-SY5Y cells. The synthesized particles were found to be highly compatible to the selected cells. It recovers the neural cell damage at the concentration of 50 μg/mL. Our formulation thus can be used as an effective drug system for neurotherapy in near future Furthermore, it was found to be capable of inhibiting apoptotic activities in the selected SH-SY5Y cells thus it execute the damage recovery mechanism. Taken as a whole, our synthesized nanomaterials significantly recover the SH-SY5Y cells from 6-OHDA induced cell damage in in vitro system. Further evaluation should be needed to optimize the prepared nanomaterials as a candidate for treating various neural related diseases.
ISSN:1040-7278
1572-8862
DOI:10.1007/s10876-019-01741-2