Synthesis of Metallic Silver Nanoparticles by Fluconazole Drug and Gamma Rays to Inhibit the Growth of Multidrug-Resistant Microbes

Here we tailored a methodology, including green synthesis of silver nanoparticles (AgNPs) in aqueous solution using Fluconazole (Fluc.), a broad-spectrum antifungal agent under the influence of gamma rays. AgNPs were characterized by UV–Vis., FTIR, XRD, DLS, and TEM image. Antimicrobial activities o...

Full description

Saved in:
Bibliographic Details
Published in:Journal of cluster science 2018-11, Vol.29 (6), p.1003-1015
Main Authors: El-Batal, Ahmed I., Mosallam, Farag M., El-Sayyad, Gharieb S.
Format: Article
Language:English
Subjects:
Antibiotics
Antimicrobial agents
Aqueous solutions
Bacteria
Biomedical materials
Catalysis
Chemical synthesis
Chemistry
Chemistry and Materials Science
Drug dosages
E coli
Fungi
Fungicides
Gamma rays
Gram-negative bacteria
Gram-positive bacteria
Infectious diseases
Inorganic Chemistry
Investigations
Microorganisms
Multidrug resistant organisms
Nanochemistry
Nanoparticles
Original Paper
Pathogens
Physical Chemistry
Radiation
Silver
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Here we tailored a methodology, including green synthesis of silver nanoparticles (AgNPs) in aqueous solution using Fluconazole (Fluc.), a broad-spectrum antifungal agent under the influence of gamma rays. AgNPs were characterized by UV–Vis., FTIR, XRD, DLS, and TEM image. Antimicrobial activities of AgNPs, Fluc., and Ag + were investigated against multidrug-resistant (MDR) bacteria and unicellular fungi. From our results, AgNPs production was found to be dependent on the concentration of Ag + , Fluc. and gamma doses. DLS with TEM image explained the size and shape of AgNPs and were found to be spherical with diameter of 11.65 nm. FTIR analysis indicates that, the hydroxyl, nitrogen and fluoride moiety in Fluc. were responsible for the reduction and binding process. AgNPs possesses antimicrobial activity against all tested microbes more than Ag + . It produced high efficacy against Acinetobacter baumannii (20.0 mm ZOI). AgNPs are synergistically active towards Candida albicans (17.0 mm ZOI). Investigated action mechanisms for AgNPs activity had been discussed. Thereby, owing to its unique features as cost-effective with continued-term stabilization, it can discover potential targets in biomedical applications and infectious diseases control.
ISSN:1040-7278
1572-8862
DOI:10.1007/s10876-018-1411-5