Enhanced Antibacterial Potential of Naringin Loaded β Cyclodextrin Nanoparticles

β-cyclodextrin (β-CD) is biocompatible and biodegradable polymer having inherent hydrophobic cavities, thus is widely used as a drug nanocarrier for less water soluble drugs. Naringin is a pharmacologically active important compound however, its therapeutic efficacy is limited due to its unique phys...

Full description

Saved in:
Bibliographic Details
Published in:Journal of cluster science 2022, Vol.33 (1), p.339-348
Main Authors: Hussain, Kashif, Ali, Imdad, Ullah, Shafi, Imran, Muhammad, Parveen, Samina, Kanwal, Tasmina, Shah, Shafiq Ali, Saifullah, Salim, Shah, Muhammad Raza
Format: Article
Language:English
Subjects:
Biocompatibility
Biodegradation
Catalysis
Chemistry
Chemistry and Materials Science
Cyclodextrins
Destabilization
Drugs
E coli
Fourier transforms
Inorganic Chemistry
Morphology
Nanochemistry
Nanoparticles
Nanotechnology
Nitrogen
Original Paper
Oxidation
Pharmacology
Physical Chemistry
Solvents
Spectrum analysis
Surface charge
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:β-cyclodextrin (β-CD) is biocompatible and biodegradable polymer having inherent hydrophobic cavities, thus is widely used as a drug nanocarrier for less water soluble drugs. Naringin is a pharmacologically active important compound however, its therapeutic efficacy is limited due to its unique physicochemical properties including lower aqueous solubility. This study reports improvement in bactericidal potentials of naringin through construction of its nano-formulation using biocompatible β-CD. Naringin loaded β-CD NPs were prepared via solvent evaporation method and characterized using various techniques such as FTIR, UV–visible spectroscopy, AFM, DSC and TGA analysis. Tetrazolium Microplate and AFM assays were used for investigating the bactericidal potential of naringin loaded β-CD NPs. Monodispersed NPs with spherical morphology of 70.00 ± 15.06 nm mean diameter were obtained that possessed net negative surface charge of − 18.20 ± 3.24 mV and were highly stable and did not change the chemical nature of the drug in various media. Antibacterial activity of naringin in β-CD NPs significantly enhanced that was authenticated by AFM, showing prominent destructive changes in the bacterial cell’s morphology through destabilization of outer membrane of bacterial cells by drug loaded NPs. Results of this study suggest that the β-CD NPs of naringin could be used as a successful formulation for developing more efficacious form of the drug against various bacterial infections.
ISSN:1040-7278
1572-8862
DOI:10.1007/s10876-020-01972-8