Development and Characterization of Phytoniosome Nano Vesicle Loaded with Aqueous Leaf Extracts of Justicia adhatoda and Psidium guajoava Against Dengue Virus (DEN-2)

The leaves of Psidium guajava (PG) and Justicia adhatoda (JA) are traditionally used in the Indian herbal medicine for the treatment of dengue. The current research work was aimed to evaluate the antiviral activity of the phytoniosomes (PN) loaded with the aqueous extracts of PG and JA (AGN) against...

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Published in:Journal of cluster science 2021-03, Vol.32 (2), p.297-304
Main Authors: Wilson, Dhanya K., Shyamala, Govindarajan, Paulpandi, Manickam, Narayanasamy, Arul, Siram, Karthik, Karuppaiah, Arjunan, Sankar, Veintramuthu
Format: Article
Language:English
Subjects:
Catalysis
Chemistry
Chemistry and Materials Science
Cholesterol
Dengue fever
Drug delivery systems
Flavonoids
Herbal medicine
Hydration
Infections
Infectious diseases
Inorganic Chemistry
Leaves
Nanochemistry
Original Paper
Particle size
Physical Chemistry
Poloxamers
Polyethylene glycol
Reagents
Room temperature
Surfactants
Thin films
Vaccines
Viruses
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description The leaves of Psidium guajava (PG) and Justicia adhatoda (JA) are traditionally used in the Indian herbal medicine for the treatment of dengue. The current research work was aimed to evaluate the antiviral activity of the phytoniosomes (PN) loaded with the aqueous extracts of PG and JA (AGN) against dengue virus-2 strain (DEN-2). The AGN were prepared by ultrasonication method using tween 80, poloxamer 407, polyethylene glycol 6000 and cholesterol. The particle size of the PN was found out to be in the range of 105.1 ± 3.6–279.4 ± 5.2 nm. In comparison to the non-PEGylated niosomes, PEGylated niosomes showed lower particle size. AGN showed in vitro antiviral activity against vero cells infected with DEN-2 virus. Capsules containing AGN powder were found to be stable for 3 months when stored at room temperature. AGN4 showed maximum of 40% plaque forming units, indicating that formulation poses significant viral inhibition in in vitro condition.
doi_str_mv 10.1007/s10876-020-01788-6
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subjects Catalysis
Chemistry
Chemistry and Materials Science
Cholesterol
Dengue fever
Drug delivery systems
Flavonoids
Herbal medicine
Hydration
Infections
Infectious diseases
Inorganic Chemistry
Leaves
Nanochemistry
Original Paper
Particle size
Physical Chemistry
Poloxamers
Polyethylene glycol
Reagents
Room temperature
Surfactants
Thin films
Vaccines
Viruses
title Development and Characterization of Phytoniosome Nano Vesicle Loaded with Aqueous Leaf Extracts of Justicia adhatoda and Psidium guajoava Against Dengue Virus (DEN-2)
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