Association of HLA DRB1 Alleles with Asthma in Pakistani Population of Punjab Region

ABSTRACT Asthma is a heterogenous disease with different endotypes. Among the various causative agents of asthma, allergens and genetic susceptibility play a key role. HLA is a complex region, and most of the GWAS studies on asthma are limited to simple gene markers. This study aimed to determine th...

Full description

Saved in:
Bibliographic Details
Published in:Pakistan journal of zoology 2024-02, Vol.56 (1), p.287
Main Authors: Bhatti, Shehar Bano, Malik, Muhammad Irfan, Khan, Rabia Faryad, Hassan, Mahmood Ul, Aslam, Muhammad Shahbaz, Abbas, Zaigham
Format: Article
Language:English
Subjects:
Alleles
Allelomorphism
Allergens
Allergies
Analysis
Asthma
Atopy
Chi-square test
Chronic obstructive pulmonary disease
Diagnosis
Distribution
Drb1 protein
Enzyme-linked immunosorbent assay
Enzymes
Genetic aspects
Genetics
Histocompatibility antigen HLA
Immunoglobulin E
Medical research
Medicine, Experimental
Patients
Population
Population genetics
Statistical analysis
Tissue typing
Tuberculosis
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:ABSTRACT Asthma is a heterogenous disease with different endotypes. Among the various causative agents of asthma, allergens and genetic susceptibility play a key role. HLA is a complex region, and most of the GWAS studies on asthma are limited to simple gene markers. This study aimed to determine the association of HLA DRB1 alleles with atopic asthma in the Pakistani population. Blood samples of 568 subjects were collected from Punjab, Pakistan. HLA typing was performed by using sequence-specific primers (SSP). Total immunoglobulin E (IgE) was estimated by ELISA. Graph pad Prism 8 was used for statistical analysis. HLA DRB1* 0701-02 and HLA DRB1* 1301-04 showed a positive association with atopic asthma having an odd's ratio (OR) of 2.173 and 3.564 respectively. While HLA DRB1* 1101-04 and HLA DRB1* 1201-02 showed a negative association having OR of 0.4853 and 0.4299 respectively. HLA DRB1* 0701-02 had a positive association with family history (p =
ISSN:0030-9923
0030-9923
DOI:10.17582/journal.pjz/20221124101151