Diacerein Loaded Poly (Styrene Sulfonate) and Carbon Nanotubes Injectable Hydrogel: An Effective Therapy for Spinal Cord Injury Regeneration

Good structural features with good conduction to transfer the electrical signal in the spinal cord are perilous in nerve soft tissue repairing materials preparation. In this research work, the electrically conductive hydrogel was prepared along with the optimal biocompatible nature of delicate nerve...

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Bibliographic Details
Published in:Journal of cluster science 2023, Vol.34 (1), p.565-576
Main Authors: Xing, Shuai, Yan, Mingzhu, Yang, Yong, Wang, Yonggang, Hu, Xuchang, Ma, Bing, Kang, Xuewen
Format: Article
Language:English
Subjects:
Anti-inflammatory agents
Biocompatibility
Carbon
Carbon nanotubes
Catalysis
Chemistry
Chemistry and Materials Science
Cytokines
Drug delivery systems
Fourier transforms
Hemodialysis
Hydrogels
Inorganic Chemistry
Morphology
Nanochemistry
Nerves
Original Paper
Physical Chemistry
Polymers
Regeneration
Sodium alginate
Soft tissues
Spectrum analysis
Spinal cord injuries
Styrenes
Tissue engineering
Tumor necrosis factor-TNF
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Summary:Good structural features with good conduction to transfer the electrical signal in the spinal cord are perilous in nerve soft tissue repairing materials preparation. In this research work, the electrically conductive hydrogel was prepared along with the optimal biocompatible nature of delicate nerve tissue. The Poly (sodium 4-styrene sulfonate) (PSS) cross-linked carbon nanotube (CNT) and sodium alginate (SA) were prepared with different ratios of SA polymer. The formation of the CNT-PSS-SA structure was characterized through Fourier Transform Infra-Red, and the interactions of the CNT with polymers were confirmed. Morphology of the hydrogel system was investigated through Transmission electron microscopy technique, and fiber-like gel morphology of the CNT and overcoated PSS, SA polymers were observed. The anti-inflammatory drug diacerein (DA) was loaded in CNT-PSS-SA-DA, and 87.0% of loading capacity was detected. The in vitro studies in human astrocyte cells (HACs) showed that CNT-PSS-SA-DA hydrogel is good cell viability. In parallel, treatment with CNT showed minimum cytotoxicity. The CNT-PSS-SA-DA treatment also effectively attenuated the proinflammatory cytokines (IL-6 and IL1β) induced by lipopolysaccharide (LPS) (10 ng/mL). These findings imply that CNT-PSS-SA hydrogels may serve as a promising candidate for drug delivery for spinal cord regeneration.
ISSN:1040-7278
1572-8862
DOI:10.1007/s10876-022-02240-7