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Anticancer Drug-Loading Capacity of Green Synthesized Porous Magnetic Iron Nanocarrier and Cytotoxic Effects Against Human Cancer Cell Line
Porous hematite α-Fe 2 O 3 nanoparticles (NPs) were synthesized using plant extract. The physicochemical characteristics of resulting porous particles were determined using X-ray diffraction (XRD), Scanning Electron Microscopy (SEM), energy dispersive X-ray (EDS), High-Resolution Transmission Electr...
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| Published in: | Journal of cluster science 2023, Vol.34 (1), p.467-477 |
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| cites | cdi_FETCH-LOGICAL-c319t-51e3188b6f4ce7cad9559c40815367a3ea8c225358a5d734d3690d0263ca1fc43 |
| container_end_page | 477 |
| container_issue | 1 |
| container_start_page | 467 |
| container_title | Journal of cluster science |
| container_volume | 34 |
| creator | Ansari, Mohammad Javed Jasim, Saade Abdalkareem Taban, Talib Zeedan Bokov, Dmitry Olegovich Shalaby, Mohammed Nader Al-Gazally, Moaed E. Kzar, Hamzah H. Qasim, Maytham T. Mustafa, Yasser Fakri Khatami, M. |
| description | Porous hematite α-Fe
2
O
3
nanoparticles (NPs) were synthesized using plant extract. The physicochemical characteristics of resulting porous particles were determined using X-ray diffraction (XRD), Scanning Electron Microscopy (SEM), energy dispersive X-ray (EDS), High-Resolution Transmission Electron Microscopy (HR-TEM), vibrating sample magnetometer (VSM) and N
2
adsorption–desorption isotherms (BET) analyses. The cytotoxicity of porous magnetic α-Fe
2
O
3
(PMΑ) NPs, free anticancer drug, and anticancer drug-coated PMΑ NPs was evaluated against melanoma cell line (A375) and normal human cells using MTT and LDH leakage assays. BET results confirmed the presence of porous particles with the mean pore diameter of 18 nm. Porous NPs have spherical surface morphology and rhombohedral crystal structures. It was revealed that both free anticancer drug and anticancer drug-coated PMΑ NPs could inhibit the cell growth in a concentration-dependent manner. However, anticancer drug-loaded PMΑ NPs had better cytotoxic effects against melanoma cell line, evidenced via MTT and LDH leakage assays. Additionally, anticancer drug-loaded PMΑ NPs induced morphological alterations compatible with the occurrence of apoptotic cell death. |
| doi_str_mv | 10.1007/s10876-022-02235-4 |
| format | article |
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2
O
3
nanoparticles (NPs) were synthesized using plant extract. The physicochemical characteristics of resulting porous particles were determined using X-ray diffraction (XRD), Scanning Electron Microscopy (SEM), energy dispersive X-ray (EDS), High-Resolution Transmission Electron Microscopy (HR-TEM), vibrating sample magnetometer (VSM) and N
2
adsorption–desorption isotherms (BET) analyses. The cytotoxicity of porous magnetic α-Fe
2
O
3
(PMΑ) NPs, free anticancer drug, and anticancer drug-coated PMΑ NPs was evaluated against melanoma cell line (A375) and normal human cells using MTT and LDH leakage assays. BET results confirmed the presence of porous particles with the mean pore diameter of 18 nm. Porous NPs have spherical surface morphology and rhombohedral crystal structures. It was revealed that both free anticancer drug and anticancer drug-coated PMΑ NPs could inhibit the cell growth in a concentration-dependent manner. However, anticancer drug-loaded PMΑ NPs had better cytotoxic effects against melanoma cell line, evidenced via MTT and LDH leakage assays. Additionally, anticancer drug-loaded PMΑ NPs induced morphological alterations compatible with the occurrence of apoptotic cell death.</description><identifier>ISSN: 1040-7278</identifier><identifier>EISSN: 1572-8862</identifier><identifier>DOI: 10.1007/s10876-022-02235-4</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Biocompatibility ; Cancer therapies ; Catalysis ; Cell death ; Chemistry ; Chemistry and Materials Science ; Chemotherapy ; Cytotoxicity ; Drug delivery systems ; Efficiency ; Ferric oxide ; Hematite ; Hemodialysis ; High resolution electron microscopy ; Inorganic Chemistry ; Leakage ; Morphology ; Nanochemistry ; Nanoparticles ; Nitrates ; Original Paper ; Penicillin ; Physical Chemistry ; Scanning electron microscopy ; Spectrum analysis ; Synthesis</subject><ispartof>Journal of cluster science, 2023, Vol.34 (1), p.467-477</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022</rights><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2022.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c319t-51e3188b6f4ce7cad9559c40815367a3ea8c225358a5d734d3690d0263ca1fc43</citedby><cites>FETCH-LOGICAL-c319t-51e3188b6f4ce7cad9559c40815367a3ea8c225358a5d734d3690d0263ca1fc43</cites><orcidid>0000-0002-7519-6998</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Ansari, Mohammad Javed</creatorcontrib><creatorcontrib>Jasim, Saade Abdalkareem</creatorcontrib><creatorcontrib>Taban, Talib Zeedan</creatorcontrib><creatorcontrib>Bokov, Dmitry Olegovich</creatorcontrib><creatorcontrib>Shalaby, Mohammed Nader</creatorcontrib><creatorcontrib>Al-Gazally, Moaed E.</creatorcontrib><creatorcontrib>Kzar, Hamzah H.</creatorcontrib><creatorcontrib>Qasim, Maytham T.</creatorcontrib><creatorcontrib>Mustafa, Yasser Fakri</creatorcontrib><creatorcontrib>Khatami, M.</creatorcontrib><title>Anticancer Drug-Loading Capacity of Green Synthesized Porous Magnetic Iron Nanocarrier and Cytotoxic Effects Against Human Cancer Cell Line</title><title>Journal of cluster science</title><addtitle>J Clust Sci</addtitle><description>Porous hematite α-Fe
2
O
3
nanoparticles (NPs) were synthesized using plant extract. The physicochemical characteristics of resulting porous particles were determined using X-ray diffraction (XRD), Scanning Electron Microscopy (SEM), energy dispersive X-ray (EDS), High-Resolution Transmission Electron Microscopy (HR-TEM), vibrating sample magnetometer (VSM) and N
2
adsorption–desorption isotherms (BET) analyses. The cytotoxicity of porous magnetic α-Fe
2
O
3
(PMΑ) NPs, free anticancer drug, and anticancer drug-coated PMΑ NPs was evaluated against melanoma cell line (A375) and normal human cells using MTT and LDH leakage assays. BET results confirmed the presence of porous particles with the mean pore diameter of 18 nm. Porous NPs have spherical surface morphology and rhombohedral crystal structures. It was revealed that both free anticancer drug and anticancer drug-coated PMΑ NPs could inhibit the cell growth in a concentration-dependent manner. However, anticancer drug-loaded PMΑ NPs had better cytotoxic effects against melanoma cell line, evidenced via MTT and LDH leakage assays. Additionally, anticancer drug-loaded PMΑ NPs induced morphological alterations compatible with the occurrence of apoptotic cell death.</description><subject>Biocompatibility</subject><subject>Cancer therapies</subject><subject>Catalysis</subject><subject>Cell death</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Chemotherapy</subject><subject>Cytotoxicity</subject><subject>Drug delivery systems</subject><subject>Efficiency</subject><subject>Ferric oxide</subject><subject>Hematite</subject><subject>Hemodialysis</subject><subject>High resolution electron microscopy</subject><subject>Inorganic Chemistry</subject><subject>Leakage</subject><subject>Morphology</subject><subject>Nanochemistry</subject><subject>Nanoparticles</subject><subject>Nitrates</subject><subject>Original Paper</subject><subject>Penicillin</subject><subject>Physical Chemistry</subject><subject>Scanning electron microscopy</subject><subject>Spectrum analysis</subject><subject>Synthesis</subject><issn>1040-7278</issn><issn>1572-8862</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kEtLxDAUhYsoOD7-gKuA62oeTZMuhzrODIwPUNfhmqa1MiZjkoL1L_inzTiCOxeXe-Ge8x04WXZG8AXBWFwGgqUoc0zpdhjPi71sQriguZQl3U83LnAuqJCH2VEIrxjjSjI2yb6mNvYarDYeXfmhy1cOmt52qIYN6D6OyLVo7o2x6GG08cWE_tM06N55NwR0A501yY-W3ll0C9Zp8L5PLLANqsfoovtI71nbGh0DmnbQ2xDRYngDmyJ-YmuzXqNVb81JdtDCOpjT332cPV3PHutFvrqbL-vpKteMVDHnxDAi5XPZFtoIDU3FeaULLAlnpQBmQGpKOeMSeCNY0bCywg2mJdNAWl2w4-x8x9149z6YENWrG7xNkYpWRDJcYiaSiu5U2rsQvGnVxvdv4EdFsNqWrnalq1S4-ildbdFsZwpJbDvj_9D_uL4BNmKFRA</recordid><startdate>2023</startdate><enddate>2023</enddate><creator>Ansari, Mohammad Javed</creator><creator>Jasim, Saade Abdalkareem</creator><creator>Taban, Talib Zeedan</creator><creator>Bokov, Dmitry Olegovich</creator><creator>Shalaby, Mohammed Nader</creator><creator>Al-Gazally, Moaed E.</creator><creator>Kzar, Hamzah H.</creator><creator>Qasim, Maytham T.</creator><creator>Mustafa, Yasser Fakri</creator><creator>Khatami, M.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7XB</scope><scope>88I</scope><scope>8FE</scope><scope>8FG</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>KB.</scope><scope>M2P</scope><scope>P5Z</scope><scope>P62</scope><scope>PDBOC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><orcidid>https://orcid.org/0000-0002-7519-6998</orcidid></search><sort><creationdate>2023</creationdate><title>Anticancer Drug-Loading Capacity of Green Synthesized Porous Magnetic Iron Nanocarrier and Cytotoxic Effects Against Human Cancer Cell Line</title><author>Ansari, Mohammad Javed ; 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2
O
3
nanoparticles (NPs) were synthesized using plant extract. The physicochemical characteristics of resulting porous particles were determined using X-ray diffraction (XRD), Scanning Electron Microscopy (SEM), energy dispersive X-ray (EDS), High-Resolution Transmission Electron Microscopy (HR-TEM), vibrating sample magnetometer (VSM) and N
2
adsorption–desorption isotherms (BET) analyses. The cytotoxicity of porous magnetic α-Fe
2
O
3
(PMΑ) NPs, free anticancer drug, and anticancer drug-coated PMΑ NPs was evaluated against melanoma cell line (A375) and normal human cells using MTT and LDH leakage assays. BET results confirmed the presence of porous particles with the mean pore diameter of 18 nm. Porous NPs have spherical surface morphology and rhombohedral crystal structures. It was revealed that both free anticancer drug and anticancer drug-coated PMΑ NPs could inhibit the cell growth in a concentration-dependent manner. However, anticancer drug-loaded PMΑ NPs had better cytotoxic effects against melanoma cell line, evidenced via MTT and LDH leakage assays. Additionally, anticancer drug-loaded PMΑ NPs induced morphological alterations compatible with the occurrence of apoptotic cell death.</abstract><cop>New York</cop><pub>Springer US</pub><doi>10.1007/s10876-022-02235-4</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-7519-6998</orcidid></addata></record> |
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| subjects | Biocompatibility Cancer therapies Catalysis Cell death Chemistry Chemistry and Materials Science Chemotherapy Cytotoxicity Drug delivery systems Efficiency Ferric oxide Hematite Hemodialysis High resolution electron microscopy Inorganic Chemistry Leakage Morphology Nanochemistry Nanoparticles Nitrates Original Paper Penicillin Physical Chemistry Scanning electron microscopy Spectrum analysis Synthesis |
| title | Anticancer Drug-Loading Capacity of Green Synthesized Porous Magnetic Iron Nanocarrier and Cytotoxic Effects Against Human Cancer Cell Line |
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