The effect of nigella supplementation on blood pressure: A systematic review and dose-response meta-analysis

This study was performed to assess the effect of nigella supplementation on blood pressure levels among the adult population. A comprehensive search was carried out through PubMed, Scopus, Web of Science, and Cochrane Library by using relevant keywords to find out the randomized clinical trials eval...

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Bibliographic Details
Published in:Critical reviews in food science and nutrition 2024, Vol.64 (4), p.943-956
Main Authors: Golpour-hamedani, Sahar, Hadi, Amir, SafariMalekabadi, Delaram, Najafgholizadeh, Ameneh, Askari, Gholamreza, Pourmasoumi, Makan
Format: Article
Language:English
Subjects:
Adult
Blood levels
Blood Pressure
Clinical trials
Dietary Supplements
Heterogeneity
Humans
Hypertension
Meta-analysis
Nigella
Pressure effects
Subgroups
Supplements
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Summary:This study was performed to assess the effect of nigella supplementation on blood pressure levels among the adult population. A comprehensive search was carried out through PubMed, Scopus, Web of Science, and Cochrane Library by using relevant keywords to find out the randomized clinical trials evaluating the effect of nigella administration on systolic blood pressure (SBP) and diastolic blood pressure (DBP). A random-effect model was applied to achieve the overall effect size. Subgroup analysis and meta-regression were used to explore the source of heterogeneity and the effects of the possible moderators. Of the twenty-two trials that were eligible for the present study, seventeen studies consisting of 1048 participants were included in the meta-analysis. The results indicated that nigella administration could significantly reduce both SBP (−4.58 mmHg; 95%CI: −6.22, −2.94) and DBP (−3.08 mmHg; 95%CI: −4.62, −1.55). Subgroup analysis did not show any superiority between subgroups of variables. Dose-response analysis detected a nonlinear association between dose and duration of administration and change in blood pressure outcomes, highlighting that maximum SBP and DBP reduction was experienced at 2000 mg/day and 8 weeks of nigella administration, respectively. The present study suggests that nigella supplementation can be beneficial for managing blood pressure.
ISSN:1040-8398
1549-7852
DOI:10.1080/10408398.2022.2110566