DNA damage in nucleosomes

Eukaryotic genomic DNA is packed into chromatin, whose fundamental structural unit is the nucleosome. As DNA-histone protein complexes, nucleosomes show different properties toward exogenous and endogenous DNA-damaging agents. This review summarizes nucleosome DNA damage due to different sources, in...

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Published in:Science China. Chemistry 2019-05, Vol.62 (5), p.561-570
Main Authors: Ren, Mengtian, Bai, Jing, Xi, Zhen, Zhou, Chuanzheng
Format: Article
Language:English
Subjects:
Alkylation
Cancer therapies
Cell death
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
DNA damage
DNA methylation
Efficiency
Free radicals
Histones
Nitrogen
Proteins
Radiation
Radiation damage
Reviews
Scavenging
Ultraviolet radiation
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container_title Science China. Chemistry
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creator Ren, Mengtian
Bai, Jing
Xi, Zhen
Zhou, Chuanzheng
description Eukaryotic genomic DNA is packed into chromatin, whose fundamental structural unit is the nucleosome. As DNA-histone protein complexes, nucleosomes show different properties toward exogenous and endogenous DNA-damaging agents. This review summarizes nucleosome DNA damage due to different sources, including alkylating agents, radicals, UV radiation and reactive DNA damage intermediates. In most cases, the histone core protects the associated DNA against damage via its structure and/or scavenging of damaging agents. In contrast, histones react with damaged DNA and, in some instances, catalyze DNA damage in the nucleosome. The biological consequence of nucleosome DNA damage and future prospects in this field are briefly discussed.
doi_str_mv 10.1007/s11426-018-9421-5
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subjects Alkylation
Cancer therapies
Cell death
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
DNA damage
DNA methylation
Efficiency
Free radicals
Histones
Nitrogen
Proteins
Radiation
Radiation damage
Reviews
Scavenging
Ultraviolet radiation
title DNA damage in nucleosomes
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