Fibrinogen-Related Proteins of Gastropoda Molluscs

Fibrinogen-related proteins (FREPs) are calcium-dependent lectins with one fibrinogen domain and one or two immunoglobulin-like domains. The FREPs of gastropod molluscs can undergo somatic diversification, which is unique among pathogen-recognizing molecules of invertebrates. The structure of the ge...

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Bibliographic Details
Published in:Biology bulletin reviews 2023, Vol.13 (Suppl 2), p.S184-S198
Main Authors: Prokhorova, E. E., Ataev, G. L.
Format: Article
Language:English
Subjects:
Alternative splicing
Biochemistry
Biomedical and Life Sciences
Calcium
Cell Biology
Ecology
Fibrinogen
Gastropoda
Immune response
Invasive species
Lectins
Life Sciences
Mollusca
Mutagenesis
Opsonization
Pathogens
Pattern recognition receptors
Zoology
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Summary:Fibrinogen-related proteins (FREPs) are calcium-dependent lectins with one fibrinogen domain and one or two immunoglobulin-like domains. The FREPs of gastropod molluscs can undergo somatic diversification, which is unique among pathogen-recognizing molecules of invertebrates. The structure of the genomic regions encoding FREPs implies the possibility of alternative splicing and somatic mutagenesis. Since the discovery of FREPs in Biomphalaria glabrata , these molecules have been described in many gastropods. At least 14 subfamilies of FREPs are currently known. FREPs of different subfamilies selectively participate in the immune response to various pathogens. In particular, their role in defense reactions to trematode invasion and resistance to trematodes of particular species has been confirmed. The supposed functions of FREPs are diverse, ranging from the recognition of foreign matter to the opsonization and neutralization of pathogens. Despite the abundance of studies of FREPs, the Russian literature on this subject is scarce. The main purpose of this review is to analyze the available information on gastropod FREPs and to discuss their role among pattern recognition receptors of molluscs.
ISSN:2079-0864
2079-0872
DOI:10.1134/S2079086423080091