A facile access for the C-N bond formation by transition metal-free oxidative coupling of benzylic C-H bonds and amides

Using 2,3-dichloro-5,6-dicyano-p-benzoquinone （DDQ） as the oxidant, we communicate an efficient oxidative C-N coupling of benzylic C-H bonds with amides to afford a series of amination products in good yields. A wide range of functional groups as well as various sulfonamides and carboxamides are wel...

Full description

Saved in:
Bibliographic Details
Published in:Science China. Chemistry 2015-08, Vol.58 (8), p.1323-1328
Main Authors: Liu, Jie, Zhang, Heng, Yi, Hong, Liu, Chao, Lei, Aiwen
Format: Article
Language:English
Subjects:
Amides
Benzoquinone
Bonding
C-H键
C-N
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Coupling
Functional groups
Oxidizing agents
Sulfonamides
Transition metals
官能团化
氧化偶联
磺胺类药物
苄基
过渡金属催化
酰胺
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Using 2,3-dichloro-5,6-dicyano-p-benzoquinone （DDQ） as the oxidant, we communicate an efficient oxidative C-N coupling of benzylic C-H bonds with amides to afford a series of amination products in good yields. A wide range of functional groups as well as various sulfonamides and carboxamides are well tolerated. Moreover, this reaction involves both the challenging C-H functionalization and C-N bond formation.
ISSN:1674-7291
1869-1870
DOI:10.1007/s11426-015-5381-2