Lanthanide-oxo clusters for efficient catalytic reduction of carboxamides

The reduction of carboxamides into high value-added amines is a very interesting but great challenging topic. Herein we demonstrate that polynuclear lanthanide-oxo clusters Ln 16 (Ln = Eu and Gd) can be used as efficient catalyst to reduce primary and secondary carboxamides to amines with excellent...

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Bibliographic Details
Published in:Science China. Chemistry 2023-02, Vol.66 (2), p.443-448
Main Authors: Weng, Zhen-Zhang, Chen, Chao-Long, Ye, Long-Wu, Long, La-Sheng, Zheng, Lan-Sun, Kong, Xiang-Jian
Format: Article
Language:English
Subjects:
Amines
Catalysts
Chemical reduction
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Clusters
Crystals
Gadolinium
Ligands
NMR
Nuclear magnetic resonance
Reagents
Substrates
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Summary:The reduction of carboxamides into high value-added amines is a very interesting but great challenging topic. Herein we demonstrate that polynuclear lanthanide-oxo clusters Ln 16 (Ln = Eu and Gd) can be used as efficient catalyst to reduce primary and secondary carboxamides to amines with excellent yield of 71%–98% and broad substrates scope. The methodology can extend to the gram-scale synthesis of phenethylamine drug with 93% yield. Based on the isolation and characterization of catalytic intermediates, a catalytic mechanism involving multipath reaction is proposed. This work provides efficient lanthanide cluster catalysts for the reduction of carboxamides to amines.
ISSN:1674-7291
1869-1870
DOI:10.1007/s11426-022-1493-y