Syntheses of amides via iodine-catalyzed multiple sp3 C-H bonds oxidation of methylarenes and sequential coupling with N,N-dialkylformamides

The oxidative coupling of methylarenes and N,N-dialkylformamides was developed, and the appropriate reaction conditions were established. By using I2 as the catalyst, and tert-butyl hydroperoxide （TBHP） as the oxidant, the reaction provided N,N-dialkylamides or N-alkylamides with moderate yields via...

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Bibliographic Details
Published in:Science China. Chemistry 2014-08, Vol.57 (8), p.1176-1182
Main Authors: Du, BingNan, Sun, PeiPei
Format: Article
Language:English
Subjects:
Amides
Butyl hydroperoxide
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Communications
Coupling
Iodine
Oxidation
Oxidizing agents
SP3
反应条件
合成
氢过氧化物
氧化偶联
烷基酰胺
碘催化
顺序耦合
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Summary:The oxidative coupling of methylarenes and N,N-dialkylformamides was developed, and the appropriate reaction conditions were established. By using I2 as the catalyst, and tert-butyl hydroperoxide （TBHP） as the oxidant, the reaction provided N,N-dialkylamides or N-alkylamides with moderate yields via multiple sp3 C-H bonds activation of methylarenes in aqueous and metal-free conditions.
ISSN:1674-7291
1869-1870
DOI:10.1007/s11426-014-5098-7