Visualization of α1-adrenergic receptors with phenylpiperazine-based fluorescent probes

Several novel fluorescent probes targetingα1-adrenergic receptors were well designed and synthesized by conjugating phenyl- piperazine pharmacophore with coumarin and fluorescein fluorophores. These compounds showed suitable fluorescence prop- erty, high receptor affinity, and low cytotoxicity. More...

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Bibliographic Details
Published in:Science China. Chemistry 2016-05, Vol.59 (5), p.624-628
Main Authors: Lin, Yuxing, Li, Wenhua, Yu, Qinying, Zhou, Xinyang, Zhang, Wei, Du, Lupei, Li, Minyong
Format: Article
Language:English
Subjects:
Chemical compounds
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Coumarin
DNA
Fluorescent indicators
Receptors (physiology)
Visualization
受体亲和力
可视化
支柱产业
细胞毒性
肾上腺素能受体
荧光探针
设计合成
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Summary:Several novel fluorescent probes targetingα1-adrenergic receptors were well designed and synthesized by conjugating phenyl- piperazine pharmacophore with coumarin and fluorescein fluorophores. These compounds showed suitable fluorescence prop- erty, high receptor affinity, and low cytotoxicity. Moreover, the cell imaging results displayed that these probes can be effec- tive tools for the real-time detection of ligand-receptor interactions, as well as the visualization and location of α1-adrenergic receptors in living cells.
ISSN:1674-7291
1869-1870
DOI:10.1007/s11426-015-5503-x