Organs on microfluidic chips：a mini review

Microfluidic technology provides opportunities to create in vitro models with physiological microenvironment for cell study.Introducing the identified key aspects,including tissue-tissue interfaces,spatiotemporal chemical gradients,and dynamic mechanical forces,of living organs into the microfluidic...

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Bibliographic Details
Published in:Science China. Chemistry 2014-03, Vol.57 (3), p.356-364
Main Authors: Jiang, Bo, Zheng, WenFu, Zhang, Wei, Jiang, XingYu
Format: Article
Language:English
Subjects:
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Microfluidics
Organs
Reviews
Toxicity testing
临床诊断
器官
微流体系统
微流控芯片
毒性测试
流控技术
生物领域
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Summary:Microfluidic technology provides opportunities to create in vitro models with physiological microenvironment for cell study.Introducing the identified key aspects,including tissue-tissue interfaces,spatiotemporal chemical gradients,and dynamic mechanical forces,of living organs into the microfluidic system,＂organs-on-chips＂display an unprecedented application potential in a lot of biological fields such as fundamental physiological and pathophysiological research,drug efficacy and toxicity testing,and clinical diagnosis.Here,we review the recent development of organs-on-chips and briefly discuss their future challenges.
ISSN:1674-7291
1869-1870
DOI:10.1007/s11426-013-4971-0