Copper-catalyzed direct oxidation and N-arylation of benzylamines with diaryliodonium salts

An efficient approach for the synthesis of N-arylated amides was developed via copper（Ⅱ） triflate-catalyzed direct oxidation of（aryl）methylamines to primary arylamides by air and subsequent N-arylation by diaryliodonium salts. Various substituted benzylamines could be applied in the reaction, provid...

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Bibliographic Details
Published in:Science China. Chemistry 2014-08, Vol.57 (8), p.1132-1136
Main Authors: Liu, Xin, Mao, Dan, Wu, ShengYing, Yu, JianJun, Hong, Gang, Zhao, Qiao, Wang, LiMin
Format: Article
Language:English
Subjects:
Amides
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Copper
Oxidation
二芳基
直接氧化
碘盐
芳基化
苄胺
酰胺
酸催化
铜催化
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Summary:An efficient approach for the synthesis of N-arylated amides was developed via copper（Ⅱ） triflate-catalyzed direct oxidation of（aryl）methylamines to primary arylamides by air and subsequent N-arylation by diaryliodonium salts. Various substituted benzylamines could be applied in the reaction, providing a series of N-arylated amides in moderate to good yields. This method showed convenient, practical, and environment friendly advantages.
ISSN:1674-7291
1869-1870
DOI:10.1007/s11426-014-5140-9