Combined training in patient with aids: improved quality of life and preserved BDNF

Objectives This study aims to investigate the impact of combined exercise training on selected health status measures and quality of life in patients with AIDS Material and methods Thirty AIDS patients were randomly divided into two groups of combined exercise training on one hand and control on the...

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Published in:Sport sciences for health 2022-03, Vol.18 (1), p.39-46
Main Authors: Khoramipour, Kayvan, Katanchi, Abbas, Hajirasouli, Masoud, Behbudi, Laleh, Basereh, Aref, Dehghan, Pooneh, Khaled, Mehdi, Chamari, Karim
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
Aerobics
AIDS
Body mass index
Brain-derived neurotrophic factor
Exercise
Fitness training programs
Heart rate
HIV
Human immunodeficiency virus
Human Physiology
Immune system
Medicine
Medicine & Public Health
Metabolic Diseases
Original Article
Participation
Patients
Physical fitness
Quality of life
Research methodology
Sports Medicine
Statistical analysis
Strength training
Variance analysis
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Summary:Objectives This study aims to investigate the impact of combined exercise training on selected health status measures and quality of life in patients with AIDS Material and methods Thirty AIDS patients were randomly divided into two groups of combined exercise training on one hand and control on the other. Combined training consisted of aerobic and resistance exercises for a duration of 12 weeks (three sessions/week). Aerobic training consisted of walking or running on a treadmill with increasing intensity from 40 to 65% of maximal heart rate for 30–60 min. Resistance sessions were made of leg press, lateral pull down, biceps curl and chest press, with 40–65% of 1-RM, two to four sets of 12–20 repetitions. Blood samples were taken from patients around 24 h before the first and 72 h after the last training sessions and cluster of differentiation four cells (CD4), serum brain-derived neurotrophic factor (BDNF), and viral load levels as well as the quality of life were assessed Results The results showed that although combined exercise training did not affect CD4 and viral load, quality of life increased significantly in the training group ( p  = 0.04). Moreover, BDNF significantly decreased in the control group but not in the training group ( p  = 0.03) Conclusions These findings suggest that combined exercise training over 3 months resulted in increased quality of life while preventing reductions in BDNF levels in AIDS patients, while no changes in viral load and CD4 count have been noticed
ISSN:1824-7490
1825-1234
DOI:10.1007/s11332-021-00771-6